SYNTHESIS AND BIOLOGICAL ACTIVITY OF SULFUR COMPOUNDS SHOWING STRUCTURAL ANALOGY WITH COMBRETASTATIN A-4 [0.03%]
具有与 Combretastatin A-4 结构类似物的硫代化合物的合成及其生物活性研究
Edson Dos A Dos Santos,Paulo C Prado,Wanderley R de Carvalho et al.
Edson Dos A Dos Santos et al.
We extended our previous exploration of sulfur bridges as bioisosteric replacements for atoms forming the bridge between the aromatic rings of combretastatin A-4. Employing coupling reactions between 5-iodo-1,2,3-trimethoxybenzene and subst...
SYNTHESIS AND BIOLOGICAL EVALUATION OF BIARYL ANALOGS OF ANTITUBULIN COMPOUNDS [0.03%]
抗微管化合物的联芳环类似物的合成及生物活性评价
Camila Santos Suniga Tozatti,Rejane Gonçalves Diniz Khodyuk,Adriano Olimpio da Silva et al.
Camila Santos Suniga Tozatti et al.
This paper reports the synthesis of methanones and esters bearing different substitution patterns as spacer groups between aromatic rings. This series of compounds can be considered phenstatin analogs. Two of the newly synthesized compounds...
Alchemy and iatrochemistry: persistent traditions in the 17th and 18th centuries [0.03%]
炼金术与医疗化学：十七至十八世纪的不灭传统
A G Debus
A G Debus