Optimal Design of Energy Systems Using Constrained Grey-Box Multi-Objective Optimization [0.03%]
基于约束灰箱多目标优化的能量系统最优设计
Burcu Beykal,Fani Boukouvala,Christodoulos A Floudas et al.
Burcu Beykal et al.
The (global) optimization of energy systems, commonly characterized by high-fidelity and large-scale complex models, poses a formidable challenge partially due to the high noise and/or computational expense associated with the calculation o...
Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins [0.03%]
阐明β-Wrapins的多靶向抗淀粉样蛋白活性及增强胰岛淀粉样多肽结合能力
Asuka A Orr,Hamed Shaykhalishahi,Ewa A Mirecka et al.
Asuka A Orr et al.
β-wrapins are engineered binding proteins stabilizing the β-hairpin conformations of amyloidogenic proteins islet amyloid polypeptide (IAPP), amyloid-β, and α-synuclein, thus inhibiting their amyloid propensity. Here, we use computation...
Big Data Approach to Batch Process Monitoring: Simultaneous Fault Detection and Diagnosis Using Nonlinear Support Vector Machine-based Feature Selection [0.03%]
基于非线性支持向量机特征选择的批量过程监控的大数据方法：同时进行故障检测与诊断
Melis Onel,Chris A Kieslich,Yannis A Guzman et al.
Melis Onel et al.
This paper presents a novel data-driven framework for process monitoring in batch processes, a critical task in industry to attain a safe operability and minimize loss of productivity and profit. We exploit high dimensional process data wit...
Multi-level Supervision and Modification of Artificial Pancreas Control System [0.03%]
人工胰腺控制系统的多级监督与修正技术研究
Jianyuan Feng,Iman Hajizadeh,Xia Yu et al.
Jianyuan Feng et al.
Artificial pancreas (AP) systems provide automated regulation of blood glucose concentration (BGC) for people with type 1 diabetes (T1D). An AP includes three components: a continuous glucose monitoring (CGM) sensor, a controller calculatin...
On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology [0.03%]
从过程系统工程到定量药物系统学的复杂生物供应链分析
Rohit T Rao,Megerle L Scherholz,Clara Hartmanshenn et al.
Rohit T Rao et al.
The use of models in biology has become particularly relevant as it enables investigators to develop a mechanistic framework for understanding the operating principles of living systems as well as in quantitatively predicting their response...
Design of an embedded inverse-feedforward biomolecular tracking controller for enzymatic reaction processes [0.03%]
基于酶反应过程的内反馈生化跟踪控制器设计
Mathias Foo,Jongrae Kim,Rucha Sawlekar et al.
Mathias Foo et al.
Feedback control is widely used in chemical engineering to improve the performance and robustness of chemical processes. Feedback controllers require a 'subtractor' that is able to compute the error between the process output and the refere...
Analysis of Finite Difference Discretization Schemes for Diffusion in Spheres with Variable Diffusivity [0.03%]
变量扩散系数的球内扩散问题的差分格式分析
Ashlee N Ford Versypt,Richard D Braatz
Ashlee N Ford Versypt
Two finite difference discretization schemes for approximating the spatial derivatives in the diffusion equation in spherical coordinates with variable diffusivity are presented and analyzed. The numerical solutions obtained by the discreti...
Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway [0.03%]
胰岛素介导的PI3K / AKT信号通路动态响应及信号传输鲁棒性的定量分析研究
Shibin Mathew,Ipsita Banerjee
Shibin Mathew
Robustness is a critical feature of signaling pathways ensuring signal propagation with high fidelity in the event of perturbations. Here we present a detailed quantitative analysis of robustness in insulin mediated PI3K/AKT pathway, a crit...
Ioannis P Androulakis
Ioannis P Androulakis
Chemical process systems engineering considers complex supply chains which are coupled networks of dynamically interacting systems. The quest to optimize the supply chain while meeting robustness and flexibility constraints in the face of e...
Design and in silico evaluation of an intraperitoneal-subcutaneous (IP-SC) artificial pancreas [0.03%]
一种腹腔内-皮下(IP-SC)人工胰腺的设计与计算机评估
Justin J Lee,Eyal Dassau,Howard Zisser et al.
Justin J Lee et al.
Prandial glucose regulation is a major challenge for the artificial pancreas using subcutaneous insulin (without a feedforward bolus) due to insulin's slow absorption-peak (50-60 min). Intraperitoneal insulin, with a fast absorption peak (2...