Analysis of Kefir Grains from Different Regions of the Planet Using High-Throughput Sequencing [0.03%]
采用高通量测序技术分析来自地球不同地区的 kefir 粒子菌群结构
F Ding,A A Krasilnikova,M R Leontieva et al.
F Ding et al.
The taxonomic composition and spatial localization of yeast and bacteria in kefir grains (KG) obtained for study from different regions of the planet were investigated. The diversity of their microbiome has been demonstrated by high-through...
Immunoinformatics Study of SARS-CoV-2 Nucleocapsid Phosphoprotein Identifies Promising Epitopes with Mutational Implications [0.03%]
免疫信息学研究SARS-CoV-2核衣壳磷酸蛋白鉴定出突变有影响的潜在表位
S Kumar,K Kumari,G K Azad
S Kumar
The SARS-CoV-2 is rapidly evolving and new mutations are being reported from different parts of the world. In this study, we investigated the variations occurring in the nucleocapsid phosphoprotein (N-protein) of SARS-CoV-2 from India. We u...
P A Nazarov,A M Kuznetsova,M V Karakozova
P A Nazarov
Antibiotic resistance is a global problem of modern medicine. A harbinger of the onset of the postantibiotic era is the complexity and high cost of developing new antibiotics as well as their inefficiency due to the rapidly developing resis...
Effect of Antioxidants on the Production of MCP-1 Chemokine by EA.hy926 Cells in Response to IL-6 [0.03%]
抗氧剂对IL-6作用于EA.hy926细胞后MCP-1趋化因子生成的影响
M A Chelombitko,I I Galkin,O Yu Pletjushkina et al.
M A Chelombitko et al.
An elevated level of circulatory interleukin 6 (IL-6) is a biomarker for cytokine storm of various etiologies, including COVID-19, and contributes to poor prognosis. Vascular endothelial cells are one of the main targets of pathological act...
Molecular Modeling of the HR2 and Transmembrane Domains of the SARS-CoV-2 S Protein in the Prefusion State [0.03%]
SARS-CoV-2 Spike蛋白在融合前状态下HR2和跨膜区域的分子建模研究
M E Bozdaganyan,P S Orekhov,D S Litvinov et al.
M E Bozdaganyan et al.
SARS-CoV-2, the causative agent of COVID-19, remains the focus of research worldwide. SARS-CoV-2 entry into the cell starts with its S protein binding to the angiotensin-converting enzyme-2 (ACE2) expressed on the cell surface. The knowledg...
Design of Nucleic Acid Biosensors Based on CRISPR/Cas Systems and Reporter Split Proteins [0.03%]
基于CRISPR/Cas系统和报告型拆分蛋白的核酸生物传感器设计
R V Novikov,A K Gribkova,J G Kacher et al.
R V Novikov et al.
Highly sensitive, specific, rapid, and easy-to-use diagnostic methods for the detection of nucleic acids of pathogens are required for the diagnosis of many human, animal, and plant diseases and environmental monitoring. The approaches base...
Kinetics of Influenza A/BANGKOK/1/1979(Н3N2) Virus Thermal Inactivation in the Presence of Polyallylamine [0.03%]
聚烯丙基胺存在下甲型流感病毒BANGKOK/1/1979（H3N2）热灭活动力学
N A Kontarov,E I Dolgova,I V Pogarskaya et al.
N A Kontarov et al.
Polyelectrolytes currently play an increasingly important role in antivirus therapy. Antiviral activity towards influenza virus, measles virus, herpes simplex virus type 1, and cytomegalovirus was demonstrated for the 6000 Da polyelectrolyt...
N V Vorobjeva
N V Vorobjeva
Neutrophils are the "first line" of defense against pathogens in the locus of inflammation, where they use effector functions such as phagocytosis, degranulation, and formation of reactive oxygen species (ROS). In 2004, Artuto Zychlinsky ch...
How Scientometrics Became the Most Important Science for Researchers of All Specialties [0.03%]
量化分析如何成为所有研究者都不可或缺的工具科学
A N Khokhlov
A N Khokhlov
The point of view of the author of this article, who participates in the work of several scientific journals, on the current situation with publishing articles by scientists of various specialties is presented. Two approaches to this proble...