The roles of phospholipase C-gamma 1 and actin-binding protein filamin A in signal transduction of the insulin receptor [0.03%]
磷脂酶C-γ1和肌动蛋白结合蛋白filamin A在胰岛素受体信号转导中的作用
Michel Bernier,Hua-Jun He,Yong-Kook Kwon et al.
Michel Bernier et al.
Familial Growth Hormone Deficiency and Mutations in the GHRH Receptor Gene [0.03%]
家族性生长激素缺乏与GHRH受体基因突变的关系
Maria Alba,Roberto Salvatori
Maria Alba
Growth hormone (GH)-releasing hormone (GHRH) is necessary for the proliferation of the somatotropic cells of the anterior pituitary and the synthesis and secretion of GH. GHRH is released by the hypothalamus into the portal hypophysial circ...
Gonadotropin-releasing hormone receptors: structure, expression, and signaling transduction [0.03%]
促性腺激素释放激素受体：结构、表达和信号转导
Sham S Kakar,M Tariq Malik,Stephen J Winters et al.
Sham S Kakar et al.
Stephan J Claes
Stephan J Claes
Major depressive disorder (MDD) is a complex disease and is one of the leading causes of disability in our society. The provoking factors are multiple; acute and chronic psychological stress, severe early trauma experiences, somatic disease...
Unusual Guanylyl Cyclases and cGMP Signaling in Dictyostelium discoideum [0.03%]
Dictyostelium discoideum中的非常规鸟苷酰环化酶和cGMP信号转导
Douwe M Veltman,Leonard Bosgraaf,Peter J M Van Haastert
Douwe M Veltman
cGMP is used as a second messenger in many eukaryotes. cGMP signaling requires at least three components: Guanylyl cyclases synthesize cGMP from GTP. Specific cGMP-binding proteins propagate the signal, usually by phosphorylation of their t...
Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP [0.03%]
胞内钙与环鸟苷酸信号的互逆调节和整合
Satish R Tiyyagura,Shiva Kazerounian,Stephanie Schulz et al.
Satish R Tiyyagura et al.
Calcium and guanosine-3',5'-cyclic monophosphate (cGMP) are second messenger molecules that regulate opposing physiological functions, reflected in the reciprocal regulation of their intracellular concentrations, in many systems. Indeed, cG...
Activation of the ligand-mineralocorticoid receptor functional unit by ancient, classical, and novel ligands. Structure-activity relationship [0.03%]
配体-盐皮质激素受体功能单元被古典型、经典型及新型配体激活的结构活性关系研究
Mario D Galigniana,G Piwien Pilipuk
Mario D Galigniana
The mineralocorticoid effect on epithelial cells is the resultant of an intricate net of biochemical regulations that ultimately leads to the maintenance of electrolyte homeostasis. Two key protagonists in this plot are the ligand, which br...
Reinterpretation of basal glucocorticoid feedback: implications to behavioral and metabolic disease [0.03%]
基础糖皮质激素反馈的再解读：对行为和代谢疾病的影响
Kevin D Laugero
Kevin D Laugero
A number of metabolic (e.g., abdominal obesity) and psychological (e.g., depression) pathologies commonly present together and have been associated with dysregulation in the hypothalamo-pituitary-adrenal (HPA) axis. Glucocorticoid hormones ...
Paul L Shaffer,Daniel T Gewirth
Paul L Shaffer
The vitamin D receptor (VDR) is a member of the steroid and nuclear hormone receptor superfamily of eukaryotic transcription factors and binds target DNA, or response elements, as a homodimer or heterodimer with the 9-cis retinoid X recepto...
Steven S Chua,Zhiqing Ma,Elly Ngan et al.
Steven S Chua et al.
The traditional role of the Cdc25 family of dual-specificity phosphatases is to activate cyclin-dependent kinases (CDKs) to enable progression through the cell cycle. This chapter reports that in addition to its cell cycle role, Cdc25B func...