Frederic Castinetti
Frederic Castinetti
Acromegaly is a chronic endocrine disorder characterized by excessive growth hormone (GH) secretion. It is typically caused by a pituitary tumor that secretes GH. Understanding the precise mechanisms that lead to tumorigenesis and GH hypers...
Eider Pascual-Corrales,José Manuel Ruiz-Cánovas,Wilfredo Antonio Rivera-Martínez
Eider Pascual-Corrales
Growth hormone (GH) is secreted in a pulsatile pattern and exerts pleiotropic effects on growth and metabolism. Beyond its role in somatic development, GH is a key regulator of glucose homeostasis through its influence on insulin signaling,...
Co-secreting pituitary adenomas in acromegaly: Classification, diagnosis, and treatment strategies [0.03%]
肢端肥大症并发的联合分泌垂体腺瘤的分类、诊断和治疗策略
Betina Biagetti,Marta Araujo-Castro
Betina Biagetti
Co-secreting pituitary adenomas (PAs) represent a subset of pituitary tumors with distinct clinical and pathological characteristics. These tumors can secrete both growth hormone (GH) and prolactin (PRL), impacting the clinical presentation...
Gabriela A Caballero,Teresa Ribalta,Iban Aldecoa
Gabriela A Caballero
Acromegaly is a chronic disorder caused by sustained excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1), most commonly due to GH-secreting pituitary neuroendocrine tumors (PitNETs), mainly limited to Pit-1 expressing lin...
Aina Raventós,Joan Gil,Montserrat Marques-Pamies et al.
Aina Raventós et al.
The management of pituitary neuroendocrine tumors (PitNETs) is shifting toward a personalized medicine approach, supported by the identification of biomarkers that can guide individualized surgical and medical strategies. In acromegaly, med...
Adriana De Sousa Lages,Valentim Lopes,Richard Anderson
Adriana De Sousa Lages
The hypothalamic pituitary gonadal (HPG) and hypothalamic pituitary somatotropic (HPS) axes are interconnected, orchestrating growth, metabolism, and reproduction through reciprocal feedback. Growth hormone (GH) and insulin like growth fact...
Acromegaly and genetics [0.03%]
肢端肥大症与遗传学
Idoia Martínez de Lapiscina,Candela Baquero,Luis Castaño
Idoia Martínez de Lapiscina
Acromegaly is a rare endocrine disorder characterized by the excessive production of growth hormone (GH) in adulthood, usually (95 percent of the time) due to a benign tumor in the pituitary gland (PitNET). Although GNAS variants are the mo...
Sara Donato,Catarina Regala,Pedro Marques
Sara Donato
Gigantism is characterized by a height greater than two standard deviation (SD) scores above the mean height for age, sex and ethnicity or more than 2 SDs above the calculated mid-parental height. Patients with accelerated growth/tall statu...
Rocío Villar-Taibo,Eva Fernández-Rodríguez,Ignacio Bernabéu
Rocío Villar-Taibo
Acromegaly is a chronic multisystem disorder driven by persistent hypersecretion of growth hormone (GH) and consequent elevation of insulin-like growth factor 1 (IGF-1). Beyond its hallmark acral and craniofacial alterations, it manifests w...
Luís Miguel Cardoso,Gabriela Silva,Bárbara Jesus et al.
Luís Miguel Cardoso et al.
The biochemical diagnosis of acromegaly presents significant challenges due to the dynamic nature of growth hormone (GH) secretion, assay variability, and the influence of both physiological and pathological factors. Measurement of serum in...