Gonadotropin-releasing hormone: gene evolution, expression, and regulation [0.03%]
促性腺激素释放激素：基因进化、表达和调节
Denise D Belsham,David A Lovejoy
Denise D Belsham
The gonadotropin-releasing hormone (GnRH) gene is a superb example of the diverse regulation that is required to maintain the function of an evolutionarily conserved and fundamental gene. Because reproductive capacity is critical to the sur...
Gareth Leng,Celine Caquineau,Nancy Sabatier
Gareth Leng
A baby sucks at a mother's breast for comfort and, of course, for milk. Milk is made in specialized cells of the mammary gland, and for a baby to feed, the milk must be released into a collecting chamber from where it can be extracted by su...
Neuroendocrine and behavioral development during puberty: a tale of two axes [0.03%]
青春期的神经内分泌和行为发育：两个轴的故事
Russell D Romeo
Russell D Romeo
Puberty is marked by dramatic changes in neuroendocrine function. These changes have profound effects on the structure and function of the maturing nervous system, resulting in altered physiological and behavioral potentials in the adult or...
Bettina von der Pahlen
Bettina von der Pahlen
The association between alcohol and aggressive behavior is well established although a direct causal relationship has proven hard to demonstrate. There are, however, indications that alcohol facilitates aggression in individuals who already...
New insights into the regulation of mammalian sex determination and male sex differentiation [0.03%]
哺乳动物性别决定及雄性分化调控的新见解
Robert S Viger,David W Silversides,Jacques J Tremblay
Robert S Viger
In mammals, sex development is a genetically and hormonally controlled process that begins with the establishment of chromosomal or genetic sex (XY or XX) at conception. At approximately 6 to 7 weeks of human gestation or embryonic day e11....
Claudia M Litterst,Stefanie Kliem,Marco Lodrini et al.
Claudia M Litterst et al.
Signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of transcription factors that relay the effect of diverse cytokines, hormones, and growth factors by regulating the transcription of distinct target g...
Soo Ok Lee,Allen C Gao
Soo Ok Lee
Novel roles for acylation stimulating protein/C3adesArg: a review of recent in vitro and in vivo evidence [0.03%]
乙酰化刺激蛋白/C3adesArg的新作用：最近体内和体外证据的回顾
Magdalena Maslowska,Hong Wei Wang,Katherine Cianflone
Magdalena Maslowska
Recent experimental evidence is shedding more light on the physiological actions of acylation-stimulating protein (ASP)/C3adesArg. The role of ASP in regulating lipid metabolism has primarily focused on its participation in the stimulation ...
ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo [0.03%]
依赖ATP的染色质重塑复合体及其在体内核受体介导的转录中的作用
Sayura Aoyagi,Kevin W Trotter,Trevor K Archer
Sayura Aoyagi
Nuclear receptors (NRs) are ligand-dependent transcription factors that mediate transcription of target genes in chromatin. Modulation of chromatin structure plays an important part in the NR-mediated transcription process. ATP-dependent ch...
Biochemical and Ionic signaling mechanisms for ACTH-stimulated cortisol production [0.03%]
刺激皮质醇产生的促肾上腺皮质激素生化和离子信号机制
John J Enyeart
John J Enyeart
Adrenocorticotropic hormone (ACTH)-stimulated cortisol production by adrenal zona fasciculata cells requires coordinated biochemical and ionic signaling mechanisms that employ adenosine 3', 5'-cyclic monophosphate (cAMP) and Ca(2+) as intra...