T van der Lende,M F W Te Pas,R F Veerkamp et al.
T van der Lende et al.
In an era of rapidly increasing prevalence of human obesity and associated health problems, leptin gene polymorphisms have drawn much attention in biomedical research. Leptin gene polymorphisms have furthermore drawn much attention from ani...
Faming Zhang,Yanyun Chen,Mark Heiman et al.
Faming Zhang et al.
Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. Leptin deficiency or resistance can result in profound obesity, diabetes, and infertility in humans. Since its discovery, our unde...
Tetsuya Ishino,Noreen Robertson,Irwin Chaiken
Tetsuya Ishino
The activation of interleukin 5 (IL-5) receptor is a dynamic process that depends on specific interaction of IL-5 with IL-5 receptor alpha, the formation of oligomeric receptor complexes with receptor beta, and the initiation of cytoplasmic...
The androgen receptor: unlocking the secrets of its unique transactivation domain [0.03%]
雄激素受体：解锁其独特转激活结构域的秘密
Howard C Shen,Gerhard A Coetzee
Howard C Shen
Whereas the androgen receptor (AR) protein shares similarities in the structure of its DNA- and hormone-binding domains with other members of the steroid nuclear receptor family, the molecule in its unliganded form has a seemingly unordered...
Henry Lardy,Ashok Marwah,Padma Marwah
Henry Lardy
Dehydroepiandrosterone (DHEA), produced from cholesterol in the adrenals, is the most abundant steroid in our circulation. It is present almost entirely as the sulfate ester, but the free steroid is the form that serves as a precursor of es...
Glucocorticoid receptor and heat shock factor 1: novel mechanism of reciprocal regulation [0.03%]
糖皮质激素受体和热休克因子1：相互调控的新机制
Dapei Li,Edwin R Sánchez
Dapei Li
Glucocorticoids control a host of bodily responses, ranging from carbohydrate metabolism in the liver to immunity and inflammation in the lymph system. In response to stress, glucocorticoid levels are known to rise-a response thought to pro...
Rebecca B Riggins,Amy H Bouton,Minetta C Liu et al.
Rebecca B Riggins et al.
Antiestrogens have been the therapeutic agents of choice for breast cancer patients whose tumors express estrogen receptors, regardless of menopausal status. Unfortunately, many patients will eventually develop resistance to these drugs. An...
G V Sherbet
G V Sherbet
Cell differentiation, proliferation, apoptosis, and cell motility are induced and regulated by a host of growth factors, vitamins, and hormones. The mode of function of these modifiers of biological response, the signaling pathways that the...
Martin J Kelly,Jian Qiu,Oline K Rønnekleiv
Martin J Kelly
Estrogen has multifaceted effects on the hypothalamus that regulate a number of homeostatic functions including reproduction, temperature, energy balance, stress, and motivated behaviors. Estrogen targets all of the major hypothalamic neuro...
Juan Bernal
Juan Bernal
The action of thyroid hormones (thyroxine, T4; triiodothyronine, T3) on brain development and function is gaining renewed interest. It has been known for many years that thyroid hormones are very important in mammalian brain maturation, inf...