Ichiro Nakamura,Eijiro Jimi
Ichiro Nakamura
Interleukin-1 (IL-1) is a multifunctional cytokine that regulates various cellular and tissue functions. Among tissues, bone is the most sensitive to IL-1. IL-1 is a potent cytokine for bone resorption and participates in the multiple steps...
The role of the interleukin-6/gp130 signaling pathway in bone metabolism [0.03%]
白细胞介素-6/GP130信号途径在骨代谢中的作用研究进展
Xin-Hua Liu,Alexander Kirschenbaum,Shen Yao et al.
Xin-Hua Liu et al.
The inhibitory effects of interleukin-1 on growth hormone action during catabolic illness [0.03%]
细胞因子IL-1对分解代谢病状态下GH作用的抑制效应
Robert N Cooney,Margaret Shumate
Robert N Cooney
Growth hormone (GH) induces the expression of the anabolic genes responsible for growth, metabolism, and differentiation. Normally, GH stimulates the synthesis of circulating insulin-like growth factor-I (IGF-I) by liver, which upregulates ...
IkappaB-zeta: an inducible regulator of nuclear factor-kappaB [0.03%]
I kappa B-zeta：一种可诱导的核因子kappa B调节物
Tatsushi Muta
Tatsushi Muta
The innate immune system responds to various microbial substances to elicit production of cytokines, chemokines, and costimulatory molecules that regulate activation of the acquired immune system. Although the transcription factor nuclear f...
NF-kappaB and cytokines [0.03%]
NF-κB和细胞因子
Dagmar Kulms,Thomas Schwarz
Dagmar Kulms
Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor...
The IL-17 cytokine family [0.03%]
IL-17细胞因子家族
Sarah L Gaffen,Jill M Kramer,Jeffrey J Yu et al.
Sarah L Gaffen et al.
IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in m...
Diana Boraschi,Aldo Tagliabue
Diana Boraschi
The cytokines IL-1 and IL-18 are key molecules both in the innate and in the adaptive immune response. Their activity is mediated by specific receptors present on the membrane of target cells. It has become apparent that these receptors are...
The newest interleukins: recent additions to the ever-growing cytokine family [0.03%]
最新白细胞介素：细胞因子大家族中的新成员
Qian Chen,Helen P Carroll,Massimo Gadina
Qian Chen
Cytokines play a critical role in the control of the innate and adaptive immune responses. The most recent additions to the ever-growing family of cytokines include interleukin (IL)-27, IL-28A, IL-28B, IL-29, IL-31, IL-32, and IL-33. Many o...
S Jaharul Haque,Pankaj Sharma
S Jaharul Haque
Metazoan cells secrete small proteins termed cytokines that execute a variety of biological functions essential for the survival of organisms. Binding of cytokines that belong to the hematopoietin- or interferon-family, to their cognate rec...
Jeffrey Jong-Young Yen,Hsin-Fang Yang-Yen
Jeffrey Jong-Young Yen
Interleukin-3 (IL-3) is one of the major hematopoietic cytokines that regulate the survival of hematopoietic cells of various lineages. Although the mechanism underlying the survival effect of IL-3 has been investigated intensively for more...