Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand [0.03%]
基因组学锚定的维生素D受体介导了其1,25-二羟基维生素D激素配体引发的大量生物保护作用
Mark R Haussler,Carol A Haussler,Peter W Jurutka
Mark R Haussler
The nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex tra...
Peter J Fuller,Morag J Young,Jun Yang et al.
Peter J Fuller et al.
The cellular response to the adrenal steroid aldosterone is mediated by the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of ligand-dependent transcription factors. The MR binds more than one physiological li...
Unraveling corticotropin-releasing factor family-orchestrated signaling and function in both sexes [0.03%]
解开促肾上腺皮质激素释放因子家族在两种性别中的信号传导和功能
Aditi Bhargava
Aditi Bhargava
Stress responses to physical, psychological, environmental, or cellular stressors, has two arms: initiation and recovery. Corticotropin-releasing factor (CRF) is primarily responsible for regulating and/or initiating stress responses via, w...
Hepcidin and its multiple partners: Complex regulation of iron metabolism in health and disease [0.03%]
他莫西汀与它的多种伙伴：健康和疾病中铁代谢的复杂调节
Yelena Z Ginzburg
Yelena Z Ginzburg
The peptide hormone hepcidin is central to the regulation of iron metabolism, influencing the movement of iron into the circulation and determining total body iron stores. Its effect on a cellular level involves binding ferroportin, the mai...
Jan-Åke Gustafsson,Xian Chang Li,Ji Ho Suh et al.
Jan-Åke Gustafsson et al.
Liver X receptors α and β are members of the nuclear receptor family, which comprise a flexible N-terminal domain, a DNA binding domain, a hinge linker, and a ligand binding domain. Liver X receptors are important regulators of cholestero...
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 [0.03%]
胰岛素和胰岛素样生长因子1和2中的假想结合位点2的突变
Jiří Jiráček,Irena Selicharová,Lenka Žáková
Jiří Jiráček
Elucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. Howeve...
Briony E Forbes
Briony E Forbes
Insulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure a...
Edward O List,Silvana Duran-Ortiz,Prateek Kulkarni et al.
Edward O List et al.
Much of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by creating mice with tissue-specific or temporal ...
Gabor Halmos,Zsuzsanna Szabo,Eva Juhasz et al.
Gabor Halmos et al.
The hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family ...
Gerald Litwack
Gerald Litwack