Ghrelin and bone [0.03%]
胃饥饿素和骨组织
Martijn van der Velde,Patric Delhanty,Bram van der Eerden et al.
Martijn van der Velde et al.
A consequence of gastrectomy is loss of bone mass. Several mechanisms have been proposed, such as malabsorption of vitamins and minerals. Additionally, a peptide hormone produced in the stomach has been shown to mediate a calcitropic effect...
Adelino F Leite-Moreira,Amândio Rocha-Sousa,Tiago Henriques-Coelho
Adelino F Leite-Moreira
Ghrelin, mainly secreted from gastric mucosa, is the endogenous ligand for the growth hormone secretagogue receptor and induces a potent release of growth hormone. Ghrelin is widely expressed in different tissues and therefore has both endo...
Andrés Giovambattista,Rolf C Gaillard,Eduardo Spinedi
Andrés Giovambattista
It is known that ghrelin and des-N-octanoyl (desacyl) ghrelin modulate food intake and adipogenesis in vivo. However, desacyl ghrelin represents the majority of ghrelin forms found in the circulation. The present study explored whether ghre...
Katsunori Nonogaki
Katsunori Nonogaki
Ghrelin is produced primarily in the stomach in response to hunger, and circulates in the blood. Plasma ghrelin levels increase during fasting and decrease after ingesting glucose and lipid, but not protein. The efferent vagus nerve contrib...
Appetite and metabolic effects of ghrelin and cannabinoids: involvement of AMP-activated protein kinase [0.03%]
生长激素释放肽和大麻素对食欲及代谢的影响：涉及AMP活化蛋白激酶的作用
Hinke van Thuijl,Blerina Kola,Márta Korbonits
Hinke van Thuijl
Obesity is one of the most important health threats to the Western world, and the physiology of appetite-regulating hormones has become a major interest in the last decades. One of the orexigenic hormones, ghrelin is the stomach-derived "br...
Yolanda Pazos,Felipe F Casanueva,Jesus P Camiña
Yolanda Pazos
The identification of the natural ligand for growth hormone secretagogue receptor 1a (GHSR1a) added a new element to the complex machinery of the physiological regulators for both growth hormone (GH) secretion and food intake. Initially, th...
Conrad Russell Young Cruz,Roy G Smith
Conrad Russell Young Cruz
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hor...
Masayasu Kojima,Takanori Ida,Takahiro Sato
Masayasu Kojima
The discovery of ghrelin has elucidated the role of the stomach as an important organ in the regulation of growth hormone (GH) release and energy homeostasis. Ghrelin is a peptide hormone in which Ser3 Thr3 in frogs) is modified by an n-oct...
Chris J Pemberton,A Mark Richards
Chris J Pemberton
Since its discovery in 1999, the stomach-derived hormone ghrelin has been studied intensively. Proghrelin is 94 amino acids long in mammals and this undergoes proteolytic processing to produce ghrelin [residues 1-28 of proghrelin(1-94)] and...
The structure of ghrelin [0.03%]
胃饥饿素的结构
Andreas Kukol
Andreas Kukol
The structure of ghrelin, a 28-residue octanoylated peptide hormone, is only known up to the level of primary structure identifying an active core of residues 1-5 or 1-4 including octanoyl-Ser3 as necessary to elicit receptor response. This...