Neurotoxic effects of metals on blood brain barrier impairment and possible therapeutic approaches [0.03%]
金属对血脑屏障损伤的神经毒性作用及可能的治疗途径
Saba Mehak Zahoor,Sara Ishaq,Touqeer Ahmed
Saba Mehak Zahoor
Exposure to neurotoxic and heavy metals (Pb2+, As3+, Mn2+, Cd2+, etc) has increased over time and has shown to negatively affect brain health. Heavy metals can cross the blood brain barrier (BBB) in various ways including receptor or carrie...
Anu Jain,Nand Kishore
Anu Jain
Accumulation of glycation products in patients with hyperglycaemic conditions can lead to their reaction with the proteins in the human system such as serum albumin, haemoglobin, insulin, plasma lipoproteins, lens proteins and collagen amon...
Christine E Delligatti,Jonathan A Kirk
Christine E Delligatti
Glycation is a protein post-translational modification that can occur on lysine and arginine residues as a result of a non-enzymatic process known as the Maillard reaction. This modification is irreversible, so the only way it can be remove...
Vitamin B6 and diabetes and its role in counteracting advanced glycation end products [0.03%]
维生素B6、糖尿病及其在对抗晚期糖基化终产物中的作用
F Vernì
F Vernì
Naturally occurring forms of vitamin B6 include six interconvertible water-soluble compounds: pyridoxine (PN), pyridoxal (PL), pyridoxamine (PM), and their respective monophosphorylated derivatives (PNP, PLP, and PMP). PLP is the catalytica...
Antioxidant and antibrowning properties of Maillard reaction products in food and biological systems [0.03%]
美拉德反应产物的抗氧化和抑褐变性能研究进展
Majid Nooshkam,Mehdi Varidi
Majid Nooshkam
Oxidative damage refers to the harm caused to biological systems by reactive oxygen species such as free radicals. This damage can contribute to a range of diseases and aging processes in organisms. Moreover, oxidative deterioration of lipi...
Breath of fresh air: Investigating the link between AGEs, sRAGE, and lung diseases [0.03%]
新鲜空气：研究AGEs、sRAGE与肺部疾病之间的联系
Charlotte Delrue,Reinhart Speeckaert,Joris R Delanghe et al.
Charlotte Delrue et al.
Advanced glycation end products (AGEs) are compounds formed via non-enzymatic reactions between reducing sugars and amino acids or proteins. AGEs can accumulate in various tissues and organs and have been implicated in the development and p...
Methylglyoxal-induced modification of myoglobin: An insight into glycation mediated protein aggregation [0.03%]
甲基乙二醛诱导肌红蛋白修饰：糖化介导的蛋白质聚集的新见解
Sauradipta Banerjee
Sauradipta Banerjee
Post-translational modification of proteins by Maillard reaction, known as glycation, is thought to be the root cause of different complications, particularly in diabetes mellitus and age-related disorders. Methylglyoxal (MG), a reactive α...
Aruna Sivaram,Nayana Patil
Aruna Sivaram
Advanced glycation end products (AGEs) are formed by the non-enzymatic attachment of carbohydrates to a biological macromolecule. These AGEs bind to their cognate receptor called receptor for AGEs (RAGEs), which becomes one of the important...
Anil K Pasupulati,Veerababu Nagati,Atreya S V Paturi et al.
Anil K Pasupulati et al.
Chronic diabetes leads to various complications including diabetic kidney disease (DKD). DKD is a major microvascular complication and the leading cause of morbidity and mortality in diabetic patients. Varying degrees of proteinuria and red...
Attenuation of albumin glycation and oxidative stress by minerals and vitamins: An in vitro perspective of dual-purpose therapy [0.03%]
矿物质和维生素联合抗白蛋白糖基化和氧化应激作用：一种双重用途疗法的体外视角
Ashwini Dinkar Jagdale,Rahul Shivaji Patil,Rashmi Santosh Tupe
Ashwini Dinkar Jagdale
Nonenzymatic glycation of proteins is accelerated in the context of elevated blood sugar levels in diabetes. Vitamin and mineral deficiencies are strongly linked to the onset and progression of diabetes. The antiglycation ability of various...