Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability [0.03%]
胶质细胞 sonic hedgehog 表达及其信号对血脑屏障通透性的调节作用
Shotaro Michinaga,Shigeru Hishinuma,Yutaka Koyama
Shotaro Michinaga
Sonic hedgehog (Shh) is a secreted glycopeptide belonging to the hedgehog family that is essential for morphogenesis during embryonic development. The Shh signal is mediated by two membrane proteins, Patched-1 (Ptch-1) and Smoothened (Smo),...
Sleep loss impairs blood-brain barrier function: Cellular and molecular mechanisms [0.03%]
睡眠不足会影响血脑屏障功能：细胞和分子机制研究
Jessica Janeth Avilez-Avilez,María Fernanda Medina-Flores,Beatriz Gómez-Gonzalez
Jessica Janeth Avilez-Avilez
Sleep is a physiological process that preserves the integrity of the neuro-immune-endocrine network to maintain homeostasis. Sleep regulates the production and secretion of hormones, neurotransmitters, cytokines and other inflammatory media...
Brain microvascular endothelial cell metabolism and its ties to barrier function [0.03%]
脑微血管内皮细胞代谢及其与屏障功能的关系
Callie M Weber,Bilal Moiz,Alisa Morss Clyne
Callie M Weber
Brain microvascular endothelial cells, which lie at the interface between blood and brain, are critical to brain energetics. These cells must precisely balance metabolizing nutrients for their own demands with transporting nutrients into th...
A circadian clock regulates the blood-brain barrier across phylogeny [0.03%]
生物钟调节血脑屏障的通透性——穿越生理学的应用研究
Ashley Avila,Shirley L Zhang
Ashley Avila
As the central regulatory system of an organism, the brain is responsible for overseeing a wide variety of physiological processes essential for an organism's survival. To maintain the environment necessary for neurons to function, the brai...
Yan Liang,Jeong-Yeol Yoon
Yan Liang
The blood-brain barrier (BBB) is a highly selective membrane that regulates the passage of substances between the bloodstream and the brain, thus safeguarding the central nervous system. This chapter provides an overview of current experime...
Jakob Körbelin,Adriana Arrulo,Markus Schwaninger
Jakob Körbelin
Endothelial cells are the building blocks of vessels in the central nervous system (CNS) and form the blood-brain barrier (BBB). An intact BBB limits permeation of large hydrophilic molecules into the CNS. Thus, the healthy BBB is a major o...
Elizabeth M Rhea,William A Banks
Elizabeth M Rhea
The blood-brain barrier (BBB) predominantly regulates insulin transport into and levels within the brain. The BBB is also an important site of insulin binding and mediator of insulin receptor (INSR) signaling. The insulin transporter is sep...
Beta-caryophyllene in psychiatric and neurological diseases: Role of blood-brain barrier [0.03%]
胡椒酚在精神病和神经系统疾病中的作用：血脑屏障的作用
Michele Pereira Mallmann,Mauro Schneider Oliveira
Michele Pereira Mallmann
Beta-caryophyllene is an abundant terpene in cannabis, cinnamon, black pepper, cloves, and citrus fruit, delivering a striking, woody-spicy, like cloves and a sweet fruity aroma. Beta-caryophyllene is a Food and Drug Administration-approved...
Sumio Ohtsuki
Sumio Ohtsuki
The blood-brain barrier (BBB) is a unique system of the brain microvasculature that limits the exchange between the blood and the brain. Brain microvascular endothelial cells form the BBB as part of the neurovascular unit and express insuli...
Neurotoxic effects of metals on blood brain barrier impairment and possible therapeutic approaches [0.03%]
金属对血脑屏障损伤的神经毒性作用及可能的治疗途径
Saba Mehak Zahoor,Sara Ishaq,Touqeer Ahmed
Saba Mehak Zahoor
Exposure to neurotoxic and heavy metals (Pb2+, As3+, Mn2+, Cd2+, etc) has increased over time and has shown to negatively affect brain health. Heavy metals can cross the blood brain barrier (BBB) in various ways including receptor or carrie...