Elías Álvarez-García,Marta Bello-Rego
Elías Álvarez-García
Aldosterone, the principal mineralocorticoid, is exclusively synthesized in the glomerular zone of the adrenal cortex. Its primary function is to maintain water and electrolyte balance and regulate blood pressure. The synthesis of aldostero...
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Petra Petranović Ovčariček,Alfredo Campennì,Rosaria Maddalena Ruggeri et al.
Petra Petranović Ovčariček et al.
Many studies, from in-vitro and in-vivo to population-based studies, demonstrate undesirable effects of higher thyroid hormone levels on the development of cancer, as well as its prognosis and consequently an outcome of cancer patients. Thy...
Robert T Chatterton Jr
Robert T Chatterton Jr
Prediagnostic serum concentrations of dehydroepiandrosterone (DHEA) and its sulfated form (DS) are generally increased in breast cancer patients; serum cortisol concentrations are predictably increased as well. The association of increased ...
Hepcidin: A multifaceted hormone in iron homeostasis and tumor biology [0.03%]
他莫西汀：铁稳态和肿瘤生物学中的多功能激素
Xiaoyu Liu,Xinyu Zhang,Yumei Fan et al.
Xiaoyu Liu et al.
Iron is an essential trace element that plays a crucial role in various biological processes, including oxygen transport, DNA synthesis and cell proliferation. Iron homeostasis is a critical biological equilibrium that involves the balance ...
Jessica R Bobbitt,Ruth A Keri
Jessica R Bobbitt
FDA approval of selective CDK4/6 inhibitors (CDK4/6i) marked a groundbreaking development in cancer treatment. Decades of pre-clinical studies elucidated the route that certain cancer cells take to gain the cancer hallmark of uncontrolled p...
B lymphoproliferative diseases: Effective treatment, inhibited progression, and potential cures through isoform-specific targeting of the prolactin receptor [0.03%]
B淋巴细胞增生性疾病：通过垂体泌乳素受体异构体特异性靶向有效治疗、抑制进展和潜在治愈方案
Srividya Swaminathan,Ameae M Walker
Srividya Swaminathan
In this chapter, we describe a potential new approach to treat lymphoproliferative diseases through isoform-specific knockdown of the long form of the prolactin receptor. The chapter includes a summary of the clinical and experimental links...
The thyroid endocrine axis in breast cancer pathophysiology and prognosis [0.03%]
甲状腺内分泌轴在乳腺癌病理生理和预后中的作用
Ioannis A Voutsadakis
Ioannis A Voutsadakis
The Estrogen Receptor (ER) is a well-established regulator of the biologic behavior of breast cancer and a biomarker of response to endocrine treatments. Other steroid and non-steroid nuclear receptors, including Progesterone Receptor (PR),...
Hypogonadism in men with prolactinoma: Diagnosis, treatment, and management of persistent hypogonadism [0.03%]
垂体泌乳素瘤男患者的低性激素血症：诊断、治疗及持续性低性激素血症的管理
Yaron Rudman,Ilan Shimon
Yaron Rudman
Prolactin-secreting adenomas comprise approximately 50 % of all clinically relevant pituitary adenomas. Most men with prolactinomas present with large and invasive tumors. Despite effective medical therapy with dopamine agonists and prolact...
Targeting epigenetic effects of androgen-androgen receptor signaling in prostate cancer [0.03%]
靶向雄激素和雄激素受体信号在前列腺癌中的表观遗传作用
Anjali Pal,Kainat,Nuzhat Bano et al.
Anjali Pal et al.
Prostate cancer (PCa) is a multifaceted and heterogeneous disease that affects men globally. PCa incidences and related deaths in men are a major clinical challenge that needs immediate attention to prevent, manage, or treat the disease to ...