Rachelle W Johnson,Julie Rhoades,T John Martin
Rachelle W Johnson
Parathyroid hormone-related protein (PTHrP) was discovered as the tumor product causing the humoral hypercalcemia of malignancy. Its structural similarity to the hormone, PTH, with 8 of the first 13 amino acids identical, was sufficient to ...
Parathyroid hormone-related protein (PTHrP)-dependent modulation of gene expression signatures in cancer cells [0.03%]
癌细胞中PTHrP依赖的基因表达特征调节
Claudio Luparello,Mariangela Librizzi
Claudio Luparello
PTHrP is encoded by PTHLH gene which can generate by alternative promoter usage and splicing mechanisms at least three mature peptides of 139, 141 and 173 amino acids with distinct carboxy terminus. PTHrP may undergo proteolytic processing ...
Ami Grunbaum,Richard Kremer
Ami Grunbaum
PTHrP (parathyroid hormone related protein) is an important mediator of malignancy-related tumor progression and hypercalcemia that shares considerable homology and functionality with parathyroid hormone. In this chapter, we review what has...
Kaushik Sarkar,Lisa Joedicke,Marta Westwood et al.
Kaushik Sarkar et al.
Parathyroid hormone receptor 1 (PTH1R) is a class B G-protein coupled receptor with key roles in bone development. The receptor signals through both the Gs and Gq G-proteins as well as through β-arrestin in a G-protein independent manner. ...
Larry J Suva,Peter A Friedman
Larry J Suva
Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) regulate extracellular phosphate and calcium homeostasis as well as bone remodeling. PTH is a classic endocrine peptide hormone whose synthesis and negative feedback by multiple fact...
Gerald Litwack
Gerald Litwack
Renata Kozyraki,Pierre Verroust,Olivier Cases
Renata Kozyraki
Cubilin (CUBN), the intrinsic factor-vitamin B12 receptor is a large endocytic protein involved in various physiological functions: vitamin B12 uptake in the gut; reabsorption of albumin and maturation of vitamin D in the kidney; nutrient d...
F Watanabe,T Bito,K Koseki
F Watanabe
The microbiological assay of total cobalamin (vitamin B12) by Lactobacillus delbrueckii subsp. lactis ATCC7830 is now used worldwide in food analysis because of its high sensitivity, low running cost, and no expensive instruments. It has be...
Wen-Sui Lo,Ralf J Sommer
Wen-Sui Lo
The round worms or nematodes are the largest phylum of animals with an estimated species number of more than one million. Nematodes have invaded all ecosystems and are known from all continents including Antarctica. Parasitic species infest...
Prashant Sahu,Harish Thippeswamy,Santosh K Chaturvedi
Prashant Sahu
Vitamin B12 deficiency can have distressing neuropsychiatric symptoms. It can have an etiological role in clinical presentations like depression, anxiety, psychosis, dementia, and delirium, requiring screening of at-risk populations. Few me...