Shahin Ahmadi,Azizeh Abdolmaleki,Marjan Jebeli Javan
Shahin Ahmadi
Antioxidants are the body's defense system against the damage of reactive oxygen species, which are usually produced in the body through various physiological processes. There are various sources of these antioxidants such as endogenous ant...
Gerald Litwack
Gerald Litwack
The parathyroid glands and parathyroid hormone: Insights from PTH gene mutations [0.03%]
甲状旁腺和甲状旁腺激素：来自PTH基因突变的新见解
Joon-Hyop Lee,Sihoon Lee
Joon-Hyop Lee
Nine mutations have been discovered in the parathyroid hormone (PTH) gene since it was initially sequenced in 1983. An autosomal dominant C18R mutation in the signal peptide was first reported in 1990, followed by an exon skipping mutation,...
Joanne Marks,Robert J Unwin
Joanne Marks
Phosphate homeostasis is dependent on the interaction and coordination of four main organ systems: thyroid/parathyroids, gastrointestinal tract, bone and kidneys, and three key hormonal regulators, 1,25-hydroxyvitamin D3, parathyroid hormon...
Primary cilia and PTH1R interplay in the regulation of osteogenic actions [0.03%]
主细胞质纤毛和PTH1R在调控成骨作用中的相互作用
Juan A Ardura,Eduardo Martín-Guerrero,Sara Heredero-Jiménez et al.
Juan A Ardura et al.
Primary cilia are subcellular structures specialized in sensing different stimuli in a diversity of cell types. In bone, the primary cilium is involved in mechanical sensing and transduction of signals that regulate the behavior of mesenchy...
Renal hyperparathyroidism [0.03%]
肾性继发性甲旁亢
Aiji Yajima,Ken Tsuchiya,Makoto Kuro-O et al.
Aiji Yajima et al.
The number of the patients with chronic kidney disease is now increasing in the world. The pathophysiology of renal hyperparathyroidism is closely associated with Klotho-FGF-endocrine axes, which must be solved definitively as early as poss...
Gene expression profiles in parathyroid adenoma and normal parathyroid tissue [0.03%]
甲状旁腺瘤和正常甲状旁腺组织的基因表达谱分析
Sang Wan Kim
Sang Wan Kim
A parathyroid adenoma comprises 80-85% as a cause of primary hyperparathyroidism. The clonal origin of most parathyroid adenomas suggests a defect at the level of the gene controlling growth of the parathyroid cell or the expression of para...
Evolution of intra-operative parathyroid hormone and its application in parathyroid surgery [0.03%]
术中降钙素的动态变化及其在甲状旁腺手术中的应用价值
Nikita Machado,Scott M Wilhelm
Nikita Machado
The history and evolution of parathyroid hormone is a true testament to inter-disciplinary collaboration among anatomists, biochemists and surgeons. The parathyroid glands were the last endocrine glands to be discovered in the mid-1800s. Ov...
Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3 [0.03%]
糖皮质激素刺激破骨细胞生成和骨吸收：与甲状旁腺素和1,25-(OH)2-维生素D3的协同作用
Petra Henning,H Herschel Conaway,Ulf H Lerner
Petra Henning
Osteoporosis is a significant health problem, with skeletal fractures increasing morbidity and mortality. Excess glucocorticoids (GC) represents the leading cause of secondary osteoporosis. The first phase of glucocorticoid-induced osteopor...
Sung-Hee Yoon,Cheng-Chia Tang,Marc N Wein
Sung-Hee Yoon
Parathyroid hormone is a central regulator of calcium homeostasis. PTH protects the organism from hypocalcemia through its actions in bone and kidney. Recent physiologic studies have revealed key target genes for PTH receptor (PTH1R) signal...