Corepressor requirement and thyroid hormone receptor function during Xenopus development [0.03%]
非洲爪蟾发育过程中甲状腺激素受体功能与核心抑制因子的需求关系研究
Laurent M Sachs
Laurent M Sachs
The biologic role of hormonal activation of nuclear receptors is well established. Only recently, however, has the biologic significance of repression begun to be appreciated. Amphibian metamorphosis is marked by dramatic thyroid hormone in...
Thyroid hormone receptor subtypes and their interaction with steroid receptor coactivators [0.03%]
甲状腺激素受体亚型及其与类固醇受体共激活因子的相互作用
Roy E Weiss,Helton E Ramos
Roy E Weiss
Thyroid hormone (TH) is required for normal growth, development, and metabolism in metazoans. To influence this broad range of physiologic actions, TH is necessarily involved in the regulation of a multitude of genes in virtually every tiss...
Rajesh S Savkur,Kelli S Bramlett,David Clawson et al.
Rajesh S Savkur et al.
The nuclear receptor (NR) superfamily comprises approximately 50 members that are responsible for regulating a number of physiologic processes in humans, including metabolism, homeostasis, and reproduction. Included in the superfamily are t...
John H White,Isabelle Fernandes,Sylvie Mader et al.
John H White et al.
Members of the nuclear receptor superfamily are ligand-regulated transcription factors that are composed of a series of conserved domains. These receptors are targets of a wide range of lipophilic signaling molecules that modulate many aspe...
Nuclear receptor recruitment of histone-modifying enzymes to target gene promoters [0.03%]
核受体募集组蛋白修饰酶到靶基因启动子上
Chih-Cheng Tsai,Joseph D Fondell
Chih-Cheng Tsai
Nuclear receptors (NRs) compose one of the largest known families of eukaryotic transcription factors and, as such, serve as a paradigm for understanding the fundamental molecular mechanisms of eukaryotic transcriptional regulation. The pac...
Structure and function of the glucocorticoid receptor ligand binding domain [0.03%]
糖皮质激素受体配体结合域的结构与功能
Randy K Bledsoe,Eugene L Stewart,Kenneth H Pearce
Randy K Bledsoe
After binding to an activating ligand, such as corticosteroid, the glucocorticoid receptor (GR) performs an impressive array of functions ranging from nuclear translocation, oligomerization, cofactor/kinase/transcription factor association,...
Ying Zhang,Maria L Dufau
Ying Zhang
Nuclear orphan receptors represent a large and diverse subgroup in the nuclear receptor superfamily. Although putative ligands for these orphan members remain to be identified, some of these receptors possess intrinsic activating, inhibitor...
Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors [0.03%]
survivin和hsp90对TRAIL诱导的细胞凋亡的抑制作用
Bharat B Aggarwal,Uddalak Bhardwaj,Yasunari Takada
Bharat B Aggarwal
The discovery of an agent that selectively kills tumor cells and not normal cells is the dream of every cancer researcher. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), first discovered in 1995, was heralded as a se...
Christine J Hawkins
Christine J Hawkins
Encouragingly, some types of cancer can now be considered treatable, with patients reasonably expecting their disease to be cured. Chemotherapy and radiation therapy are effective against these cancers because they activate the so-called in...
Young E Whang,Xiu-Juan Yuan,Yuanbo Liu et al.
Young E Whang et al.
The ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis preferentially in cancer cells is attractive for its development as a novel cancer therapeutic agent, but many cancer cell lines are resistan...