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Endocannabinoid system and epigenetics in spermatogenesis and testicular cancer [0.03%]
大麻素系统和表观遗传学在精子发生和睾丸癌中的作用
Marco Barchi,Eugenia Guida,Susanna Dolci et al.
Marco Barchi et al.
In mammals, male germ cell development starts during fetal life and is carried out in postnatal life with the formation of sperms. Spermatogenesis is the complex and highly orderly process during which a group of germ stem cells is set at b...
Epigenetic regulation during 1,25-dihydroxyvitamin D3-dependent gene transcription [0.03%]
1,25-二羟基维生素D3依赖的基因转录的表观遗传调控
Daniel Moena,Esther Vargas,Martin Montecino
Daniel Moena
Multiple evidence accumulated over the years, demonstrates that vitamin D-dependent physiological control in vertebrates occurs primarily through the regulation of target gene transcription. In addition, there has been an increasing appreci...
Loredana Verdone,Micaela Caserta,Tal Dotan Ben-Soussan et al.
Loredana Verdone et al.
Many environmental and lifestyle related factors may influence the physiology of the brain and body by acting on fundamental molecular pathways, such as the hypothalamus-pituitary-adrenal axis (HPA) and the immune system. For example, stres...
Mario F Juruena
Mario F Juruena
Different factors are essential in increasing the vulnerability to psychiatric disorders, such as genetics. Among these factors, early life stress (ELS), including sexual, physical, emotional abuse, and emotional and physical neglect, enhan...
Ayman Mukerji Househam
Ayman Mukerji Househam
Epigenetics are heritable changes in the rate of gene expression without any modification of the DNA sequence and occur in response to environmental changes. Tangible changes to the external surroundings may be practical causes for epigenet...
Crosstalk between epigenetics and tumor promoting androgen signaling in prostate cancer [0.03%]
前列腺癌中表观遗传与促肿瘤雄激素信号间的相互影响
Vipendra Kumar Singh,K M Kainat,Pradeep Kumar Sharma
Vipendra Kumar Singh
Prostate cancer (PCa) is one of the major health burdens among all cancer types in men globally. Early diagnosis and efficacious treatment options are highly warranted as far as the incidence of PCa is concerned. Androgen-dependent transcri...
Early-life AFB1 exposure: DNA methylation and hormone alterations [0.03%]
黄曲霉毒素B1暴露与DNA甲基化及激素改变的关系研究
Oluwakemi A Rotimi,Opeyemi C De Campos,Isaacson B Adelani et al.
Oluwakemi A Rotimi et al.
Aflatoxins are secondary metabolites of mold that contaminate food and feedstuff. They are found in various food including grains, nuts, milk and eggs. Aflatoxin B1 (AFB1) is the most poisonous and commonly found of the various types of afl...
Epigenetic developmental programming and intergenerational effects of thyroid hormones [0.03%]
甲状腺激素的表观遗传发育编程和跨世代效应
Arturo Hernandez,M Elena Martinez,Carolina Chaves et al.
Arturo Hernandez et al.
Mounting evidence is showing that altered signaling through the nuclear hormone receptor superfamily can cause abnormal, long-term epigenetic changes which translate into pathological modifications and susceptibility to disease. These effec...
Aberrant epigenetic regulation of estrogen and progesterone signaling at the level of endometrial/endometriotic tissue in the pathomechanism of endometriosis [0.03%]
子宫内膜异位症发病机制中子宫内膜/子宫内膜异位组织水平上雌激素和孕激素信号的异常表观调控
Dariusz Szukiewicz
Dariusz Szukiewicz
Endometriosis is a term referring to a condition whereby the endometrial tissue is found outside the uterine cavity. This progressive and debilitating condition affects up to 15% of women of reproductive age. Due to the fact that endometrio...