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Petra Petranović Ovčariček,Alfredo Campennì,Rosaria Maddalena Ruggeri et al.
Petra Petranović Ovčariček et al.
Many studies, from in-vitro and in-vivo to population-based studies, demonstrate undesirable effects of higher thyroid hormone levels on the development of cancer, as well as its prognosis and consequently an outcome of cancer patients. Thy...
Robert T Chatterton Jr
Robert T Chatterton Jr
Prediagnostic serum concentrations of dehydroepiandrosterone (DHEA) and its sulfated form (DS) are generally increased in breast cancer patients; serum cortisol concentrations are predictably increased as well. The association of increased ...
Hepcidin: A multifaceted hormone in iron homeostasis and tumor biology [0.03%]
他莫西汀：铁稳态和肿瘤生物学中的多功能激素
Xiaoyu Liu,Xinyu Zhang,Yumei Fan et al.
Xiaoyu Liu et al.
Iron is an essential trace element that plays a crucial role in various biological processes, including oxygen transport, DNA synthesis and cell proliferation. Iron homeostasis is a critical biological equilibrium that involves the balance ...
Jessica R Bobbitt,Ruth A Keri
Jessica R Bobbitt
FDA approval of selective CDK4/6 inhibitors (CDK4/6i) marked a groundbreaking development in cancer treatment. Decades of pre-clinical studies elucidated the route that certain cancer cells take to gain the cancer hallmark of uncontrolled p...
B lymphoproliferative diseases: Effective treatment, inhibited progression, and potential cures through isoform-specific targeting of the prolactin receptor [0.03%]
B淋巴细胞增生性疾病：通过垂体泌乳素受体异构体特异性靶向有效治疗、抑制进展和潜在治愈方案
Srividya Swaminathan,Ameae M Walker
Srividya Swaminathan
In this chapter, we describe a potential new approach to treat lymphoproliferative diseases through isoform-specific knockdown of the long form of the prolactin receptor. The chapter includes a summary of the clinical and experimental links...
The thyroid endocrine axis in breast cancer pathophysiology and prognosis [0.03%]
甲状腺内分泌轴在乳腺癌病理生理和预后中的作用
Ioannis A Voutsadakis
Ioannis A Voutsadakis
The Estrogen Receptor (ER) is a well-established regulator of the biologic behavior of breast cancer and a biomarker of response to endocrine treatments. Other steroid and non-steroid nuclear receptors, including Progesterone Receptor (PR),...
Hypogonadism in men with prolactinoma: Diagnosis, treatment, and management of persistent hypogonadism [0.03%]
垂体泌乳素瘤男患者的低性激素血症：诊断、治疗及持续性低性激素血症的管理
Yaron Rudman,Ilan Shimon
Yaron Rudman
Prolactin-secreting adenomas comprise approximately 50 % of all clinically relevant pituitary adenomas. Most men with prolactinomas present with large and invasive tumors. Despite effective medical therapy with dopamine agonists and prolact...
Targeting epigenetic effects of androgen-androgen receptor signaling in prostate cancer [0.03%]
靶向雄激素和雄激素受体信号在前列腺癌中的表观遗传作用
Anjali Pal,Kainat,Nuzhat Bano et al.
Anjali Pal et al.
Prostate cancer (PCa) is a multifaceted and heterogeneous disease that affects men globally. PCa incidences and related deaths in men are a major clinical challenge that needs immediate attention to prevent, manage, or treat the disease to ...
Histopathological features of aldosterone-producing lesions according to their different somatic genetic mutations [0.03%]
不同体细胞基因突变引起的醛固酮增多症病变的病理特征分析
Xin Gao,Yuto Yamazaki,Yoshikiyo Ono et al.
Xin Gao et al.
Primary aldosteronism (PA) is composed of different aldosterone-producing lesions including aldosterone-producing adenoma (APA), aldosterone-producing micronodules (APM), aldosterone-producing nodules (APN) and aldosterone-producing diffuse...