Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why? [0.03%]
鳞状细胞 carcinoma为何不响应1,25(OH)2D促分化的作用？
Daniel D Bikle,Zhongjian Xie,Dean Ng et al.
Daniel D Bikle et al.
1,25(OH)2D regulates a number of cellular events which contribute to its ability to stimulate differentiation of the keratinocyte. 1,25(OH)2D raises the intracellular calcium (Cai) level in part by increasing the expression of the calcium r...
Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation [0.03%]
1,25(OH)2D3在前列腺癌和乳腺癌中的抗增殖信号通过组蛋白去乙酰化机制受到抑制
Claire M Banwell,Rena Singh,Paul M Stewart et al.
Claire M Banwell et al.
Breast and prostate cancer are leading causes of cancer death in the Western world. Hormone ablation is the primary therapy for invasive disease, but the tumour often recurs in an androgen or oestrogen receptor negative form for which novel...
Ligand structure-function relationships in the vitamin D endocrine system from the perspective of drug development (including cancer treatment) [0.03%]
从药物开发（包括癌症治疗）的角度看维生素D内分泌系统的配体结构功能关系
Anthony W Norman,Mathew T Mizwicki,William H Okamura
Anthony W Norman
It has become readily apparent to many scientists and pharmaceutical companies that the vitamin D endocrine system offers a wide array of drug development opportunities. There are already successes, as noted by 1alpha,25(OH)2D3 (Roche, and ...
Approaches to evaluating the association of vitamin D receptor gene polymorphisms with breast cancer risk [0.03%]
用于评估维生素D受体基因多态性与乳腺癌风险关联的研究方法
Michelle Guy,Lorraine C Lowe,Deborah Bretherton-Watt et al.
Michelle Guy et al.
The steroid hormone 1,25 dihydroxyvitamin D3 is thought to protect against breast cancer. Its actions are mediated via the vitamin D receptor (VDR) and a number of polymorphisms in the VDR gene have been identified, some of which may alter ...
Current understanding of the function of the nuclear vitamin D receptor in response to its natural and synthetic ligands [0.03%]
当前关于维甲酸核受体功能及其对天然配体和合成配体反应的理解
Carsten Carlberg
Carsten Carlberg
The vitamin D receptor (VDR), the high affinity receptor for 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), is a member of the nuclear receptor superfamily. VDR preferentially forms a heterodimeric complex with the retinoid X receptor (R...
Michael F Holick
Michael F Holick
It is remarkable that phytoplankton and zooplankton have been producing vitamin D for more than 500 million years. The role of vitamin D in lower non-vertebrate life forms is not well understood. However, it is critically important that mos...
Summary and congress report: molecular staging of cancer--concepts of today, therapies of tomorrow [0.03%]
分子分期与癌症报告：今日概念，明日疗法
Heike Allgayer,Markus M Heiss,Friedrich W Schildberg
Heike Allgayer
Recurrences of thyroid cancer after radical surgery and complementary treatment: are macroscopic, microscopic, scintigraphic, and biochemical criteria sufficient in the evaluation of radicality of primary treatment? [0.03%]
甲状腺癌根治术后复发与辅助治疗后的宏观、微观、扫描及生化指标对初次手术的根治性评估是否充分？
Lech Pomorski,Jacek Cywiński,Krzysztof Kołomecki et al.
Lech Pomorski et al.
From 1974 to 1999, 1,001 patients were operated on for thyroid cancer, including 778 (78%) for differentiated thyroid cancer and 223 (22%) for other thyroid malignant neoplasms. Radical operations were performed in 716 (92%) patients with d...
Molecular whole-body cancer staging using positron emission tomography: consequences for therapeutic management and metabolic radiation treatment planning [0.03%]
利用正电子发射体层摄影进行分子全身癌症分期及其对治疗处理和代谢性放射治疗计划的影响
Michael Schmücking,Richard P Baum,Frank Griesinger et al.
Michael Schmücking et al.
A prospective analysis was performed in 124 non-small cell lung cancer patients to determine the role of F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) for molecular (metabolic) staging (n=63), therapy monitoring after ind...
Evaluation of the levels of bFGF, VEGF, sICAM-1, and sVCAM-1 in serum of patients with thyroid cancer [0.03%]
甲状腺癌患者血清中bFGF、VEGF、sICAM-1和sVCAM-1水平的检测分析
Zbigniew Pasieka,Henryk Stepień,Jan Komorowski et al.
Zbigniew Pasieka et al.
Tumour growth and development depend on a complex cascade of angiogenic factors. The aim of the study is evaluation of the level of growth factors VEGF and bFGF, and adhesion molecules sICAM-1, sVCAM-1 in the serum of patients with papillar...