Marco Ruiz Santillan,Ramona Dadu,Robert F Gagel et al.
Marco Ruiz Santillan et al.
Medullary thyroid carcinoma (MTC) is a rare disease that is indolent in the majority of patients. In a subset of patients, the cancer is more aggressive with symptomatic or progressive disease metastasizing to cervical neck structures, lung...
Friedhelm Raue,Karin Frank-Raue
Friedhelm Raue
After surgery, patients with MTC (medullary thyroid carcinoma) should be assessed for the presence of residual disease, the localization of metastases, and the identification of progressive disease. Postoperative staging is used to separate...
Andreas Machens,Henning Dralle
Andreas Machens
Medullary thyroid cancer (MTC) is an infrequent calcitonin-secreting thyroid malignancy that can vary a great deal in tumor biology and progression. The most important determinant of distant metastases, which represents the single greatest ...
Katerina Saltiki,Maria Alevizaki
Katerina Saltiki
One of the components of the classical form of MEN2 syndromes is primary hyperparathyroidism (PHP). It occurs in 20-30% of the typical MEN2A syndrome. Recently, the prevalence in ret gene carriers is rarer possibly due to the increased reco...
Pheochromocytoma in MEN2 [0.03%]
MEN2中的嗜铬细胞瘤
Matti L Gild,Kimchi Do,Venessa H M Tsang et al.
Matti L Gild et al.
Pheochromocytomas (PCs) are rare neuroendocrine tumors found in 20-50% of MEN2 patients. MEN2-related PCs are more often bilateral, identified at a younger age and have a low metastatic potential. They secrete epinephrine as the predominant...
Karin Frank-Raue,Friedhelm Raue
Karin Frank-Raue
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant hereditary cancer syndrome caused by germline variants in the REarranged during Transfection (RET) proto-oncogene. MEN2 is caused by autosomal dominant gain-of-function mut...
Yoon Ju Bae,Michael Schaab,Jüergen Kratzsch
Yoon Ju Bae
Calcitonin (CTN) is a polypeptide hormone consisting of 32 amino acids with a disulfide bridge between position 1 and 7 that is mainly produced by the C-cells of thyroid gland. The measurement of CTN concentrations in blood reflects C-cell ...
Stefan Delorme,Friedhelm Raue,Bettina Beuthien-Baumann
Stefan Delorme
Imaging plays an important role in the early detection and staging of medullary thyroid carcinoma (MTC), as well as in follow-up to locate early recurrence. MTC is a rare, calcitonin-secreting thyroid malignancy that is often diagnosed by u...
Epidemiology, Clinical Presentation, and Diagnosis of Medullary Thyroid Carcinoma [0.03%]
髓样甲状腺癌的流行病学、临床表现及诊断
Friedhelm Raue,Karin Frank-Raue
Friedhelm Raue
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from thyroid C cells that produces mainly calcitonin (Ctn) and is used as a tumor marker. MTC can occur either sporadically (75%) or in a hereditary variant (multi...
Rozita Bagheri-Yarmand,Elizabeth G Grubbs,Marie-Claude Hofmann
Rozita Bagheri-Yarmand
The thyroid parafollicular cell, or commonly named "C-cell," functions in serum calcium homeostasis. Elevations in serum calcium trigger release of calcitonin from the C-cell, which in turn functions to inhibit absorption of calcium by the ...