Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer [0.03%]
维生素D系统在宫颈癌、乳腺癌和卵巢癌中的分析研究
Michael Friedrich,Leyla Rafi,Tanja Mitschele et al.
Michael Friedrich et al.
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) is the biologically active metabolite of vitamin D and has been shown to regulate the growth of various cell types. There are two principal enzymes involved in the formation of circulating 1,25(OH)2D3 ...
Lilin Wang,Lyman W Whitlatch,John N Flanagan et al.
Lilin Wang et al.
25-Hydroxyvitamin D-1alpha-hydroxylase (lalpha-OHase) is expressed in prostate cells. The expression suggests that local production of 1,25-dihydroxyvitamin D could provide an important cell growth regulatory mechanism. However, there is di...
Aruna V Krishnan,Donna M Peehl,David Feldman
Aruna V Krishnan
Prostate cancer (PCa) cells harbor receptors for vitamin D (VDR) as well as androgens (AR). 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] increases AR expression and enhances androgen actions linking the two receptor systems. 1,25(OH)2D3 exhibits ...
Importance of cytochrome P450-mediated metabolism in the mechanism of action of vitamin D analogs [0.03%]
细胞色素P450介导的代谢在维生素D类似物作用机制中的重要性
Sonoko Masuda,Mian Gao,Anqi Zhang et al.
Sonoko Masuda et al.
The elucidation of the metabolic pathway for vitamin D, including the delineation of the specific cytochrome P450s (CYPs) involved in activation and catabolism, has emphasized the overall importance of metabolic considerations in vitamin D ...
Combination of vitamin D metabolites with selective inhibitors of vitamin D metabolism [0.03%]
维生素D代谢物与维生素D代谢的特异性抑制剂的联合应用
Inge Schuster,Helmut Egger,G Satyanarayana Reddy et al.
Inge Schuster et al.
1alpha,25(OH)2D3 exerts antiproliferative, differentiating effects on many cell types, including cancer tissues. In most of its target cells, levels of 1alpha,25(OH)2D3 are regulated by local synthesis via CYP27B and metabolism via CYP24. R...
Regulation of the 25-hydroxyvitamin D-1alpha-hydroxylase gene and its splice variant [0.03%]
25-羟维生素D-1α-羟化酶基因及其剪切变异体的调控机制研究
John N Flanagan,Lilin Wang,Vin Tangpricha et al.
John N Flanagan et al.
The 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) is responsible for producing the active form of vitamin D, 1alpha,25-dihydroxyvitamin D. The enzyme not only is expressed in kidneys, but also is expressed in many nonrenal tissues, includ...
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression? [0.03%]
胶质母细胞瘤中25-羟基维生素D3 1，alpha-环氧化酶（CYP27B1）的基因扩增和剪接变异体——可能在肿瘤进展中发挥作用？
Britta Diesel,Ulrike Fischer,Eckart Meese
Britta Diesel
We report a gene amplification of 25-hydroxyvitamin D3 1,alpha-hydroxylase and the appearance of various splice variants in glioblastoma multiforme. Some protein products of the widespread expressed variants may exert a biological function....
Cultured rat growth plate chondrocytes express low levels of 1alpha-hydroxylase [0.03%]
大鼠生长板软骨细胞表达低水平的1α-羟化酶
Lutz Weber,Ulrike Hügel,Jørg Reichrath et al.
Lutz Weber et al.
Growth plate chondrocytes are the target of the hydroxylated vitamin D metabolites 1alpha,25(OH)2D3 and 24,25(OH)2D3. Because studies on the production of these polar metabolites were inconclusive in various in vitro systems, the expression...
Extrarenal sites of calcitriol synthesis: the particular role of the skin [0.03%]
肾外部位的calcitriol合成：皮肤的特殊作用
Bodo Lehmann,Michael Meurer
Bodo Lehmann
Calcitriol (1alpha,25(OH)2D3), the hormonally active form of vitamin D3 (D3) is produced by a cascade of reactions, including photochemical D3 synthesis in the skin and subsequent hydroxylation at the C-25 atom in the liver and finally at C...
A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis [0.03%]
一种新的维生素D调节的早期基因IEX-1可改变细胞生长和凋亡
Rajiv Kumar,Mark R Pittelkow,Jeffrey L Salisbury et al.
Rajiv Kumar et al.
1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular ...