William B Grant
William B Grant
Solar ultraviolet B (UV-B) radiation (280-320 nm) has been associated with reduced risk of cancer of the breast, colon, ovary, and prostate, as well as non-Hodgkin's lymphoma (NHL) through the production of vitamin D in papers extending bac...
The role of reactive oxygen species in the anticancer activity of vitamin D [0.03%]
活性氧在维生素D抗肿瘤作用中的角色
Amiram Ravid,Ruth Koren
Amiram Ravid
Calcitriol, the hormonal form of vitamin D, enhances the anticancer activity of the immune cytokine tumor necrosis factor, interleukin 1 and interleukin 6 in human breast and renal cell carcinoma cells without affecting the cytotoxic action...
Prospects for vitamin D receptor modulators as candidate drugs for cancer and (auto)immune diseases [0.03%]
维生素D受体调节剂作为癌症和自身免疫性疾病候选药物的前景
Roger Bouillon,Annemieke Verstuyf,Lieve Verlinden et al.
Roger Bouillon et al.
The development of less calcemic vitamin D analogs creates possible therapeutic applications for immune modulation (e.g., autoimmune diseases and graft rejection), inhibition of cell proliferation and induction of cell differentiation (e.g....
A low-calcemic vitamin D analog (Ro 25-4020) inhibits the growth of LNCaP human prostate cancer cells with increased potency by producing an active 24-oxo metabolite (Ro 29-9970) [0.03%]
一种低升钙作用的维生素D类似物（Ro 25-4020）通过产生活性24-酮代谢产物（Ro 29-9970）以更强效的作用抑制LNCaP人类前列腺癌细胞生长
Srilatha Swami,Xian-Yan Zhao,Stephen Sarabia et al.
Srilatha Swami et al.
In this study, we have characterized a novel less-calcemic vitamin D analog Ro 25-4020 (1alpha, 25 dihydroxy-16-ene-5,6-trans-vitamin D3) and investigated the mechanisms underlying its enhanced growth inhibitory properties. We found that Ro...
James O&#x;Kelly,H Phillip Koeffler
James O&#x;Kelly
Breast cancer is the most frequent malignancy of women in the Western world. Vitamin D compounds constitute a novel alternative to the conventional use of antiestrogens for chemoprevention and chemotherapy. The biologically active form of v...
Induction of apoptosis by vitamin D metabolites and analogs in a glioma cell line [0.03%]
维甲酸和维生素D诱导恶性胶质细胞凋亡及相关信号转导路径的研究
Josef Elias,Brigitte Marian,Christa Edling et al.
Josef Elias et al.
Gliomas are the most common malignant tumors in brain. Recent studies demonstrate the capacity of 1alpha,25(OH)2D3 to specifically induce cell death (apoptosis) in model glioma cell lines and in primary cultures from tumor tissue, but not i...
Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs [0.03%]
A环修饰的1,25-二羟基维生素D3类似物的设计、合成及生物活性研究
Hiroaki Takayama,Atsushi Kittaka,Toshie Fujishima et al.
Hiroaki Takayama et al.
Antitumor effects of 1alpha,25-dihydroxyvitamin D3 analogs have recently become one of the major topics of the vitamin D research field. We focused on the structure-activity relationships of the A-ring moiety of the vitamin D molecule and f...
Evaluation of vitamin D analogs as therapeutic agents for prostate cancer [0.03%]
评估维生素D类似物作为前列腺癌治疗药物的效果
Tai C Chen,Michael F Holick,Bal L Lokeshwar et al.
Tai C Chen et al.
Prostate cancer cells contain specific receptors (VDR) for la,25-dihydroxyvitamin D (1alpha,25(OH)2D), which is known to inhibit the proliferation and invasiveness of these cells. These findings support the use of 1alph,25(OH)2D for prostat...
Jörn Kamradt,Leyla Rafi,Tanja Mitschele et al.
Jörn Kamradt et al.
1,25-dihydroxyvitamin D3, the biological active metabolite of vitamin D, has great impact on keratinocyte growth and differentiation, and consequently has already been successfully used in the therapy of hyperproliferative skin disorders. W...
Short-chain fatty acids and colon cancer cells: the vitamin D receptor--butyrate connection [0.03%]
短链脂肪酸与结肠癌细胞的相互作用：维生素D受体-丁酸连接点
Tanja Gaschott,Jürgen Stein
Tanja Gaschott
Butyrate and its prodrug tributyrin, as well as 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), have important physiological effects on proliferation and differentiation in a variety of malignant cells. The aim of this study was to elucidate the r...