Mukesh Verma,Sudhir Srivastava
Mukesh Verma
Cancer is not a single disease but an accumulation of several events, genetic and epigenetic, arising in a single cell over a long time interval. A high priority in the cancer field is to identify these events. This can be achieved by chara...
Eugene W Gerner,Natalia A Ignatenko,David G Besselsen
Eugene W Gerner
Colon cancer is the second leading cause of cancer incidence and death in the USA in 2002. Specific genetic defects have been identified which cause hereditary colon cancers in humans. In addition, a number of intestinal luminal risk factor...
Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs [0.03%]
小鼠皮肤炎症化学预防模型评价非甾体抗炎药的作用
Friedrich Marks,Gerhard Fürstenberger,Gitta Neufang et al.
Friedrich Marks et al.
The mouse skin model of multistage carcinogenesis has demonstrated that cancer results from a synergism between genotoxic and nongenotoxic factors. The former induce irreversible genetic alterations, whereas the latter promote tumor develop...
Development of novel selective cell ablation in the mammary gland and brain to study cell-cell interactions and chemoprevention [0.03%]
乳腺和大脑中新型选择性细胞消融的开发以研究细胞-细胞相互作用和化学预防
Barry A Gusterson,Wei Cui,A John Clark
Barry A Gusterson
We have generated transgenic mice which express the gene encoding Escherichia coli nitroreductase (NTR) specifically in the luminal epithelial cells of the mammary gland and the glial cells of the brain. The enzyme activates an antitumour d...
Novel approaches to identify low-penetrance cancer susceptibility genes using mouse models [0.03%]
利用小鼠模型鉴定低 penetrance 肿瘤易感基因的新方法
John P de Koning,Jian-Hua Mao,Allan Balmain
John P de Koning
Studies of cancer predisposition have largely concentrated on the role of high-penetrance susceptibility genes. Less than 10% of the total human tumor burden, however, is accounted for by mutations in these genes. More genetic variation in ...
Paul D P Pharoah
Paul D P Pharoah
A polygenic approach to disease prevention has become a realistic goal that has arisen from the sequencing of the human genome. Some believe it will be possible to identify individuals as susceptible by their genotype and to prevent disease...
Modulation of X-ray-induced apoptosis in human keratinocytes (HaCaT) by 1,25-dihydroxyvitamin D3 [0.03%]
1,25-二羟基维生素D3对X射线所致的人永生化角质细胞凋亡的调控作用
Viktor Meineke,Carolina Pfaffendorf,Michaela Schinn et al.
Viktor Meineke et al.
Possible effects of 1,25-dihydoxyvitamin D3 (vitamin D) on ionizing radiation-induced cell damage have been unknown until now. The task of the present study was to analyze, in a human keratinocyte cell line (HaCaT), the effects of a preincu...
Regulation of extrarenal vitamin D metabolism as a tool for colon and prostate cancer prevention [0.03%]
调节非肾脏维生素D代谢作为预防结肠癌和前列腺癌的工具
Heide S Cross,Enikö Kállay,Hesso Farhan et al.
Heide S Cross et al.
Though 1,25-dihydroxyvitamin D3 (1,25-D3) as well as some vitamin D analogs have an antimitotic as well as a differentiating action, therapeutic application in tumor patients is still precluded due to their hypercalcemic action at the neces...
Efficacy and mechanism of action of 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha[OH]D5) in breast cancer prevention and therapy [0.03%]
1α-羟基-24-乙烯胆钙化醇(1α[OH]D5)在乳腺癌预防和治疗中的有效性和作用机制
Erum A Hussain,Rajeshwari R Mehta,Rahul Ray et al.
Erum A Hussain et al.
It is now well established that the active metabolite of vitamin D3, 1alpha,25(OH)2D3, regulates cell growth and differentiation in various in vitro cancer models. However, its clinical use is precluded due to its hypercalcemic activity in ...
Phytoestrogens and 17beta-estradiol influence vitamin D metabolism and receptor expression-relevance for colon cancer prevention [0.03%]
植物雌激素和雌二醇影响维生素D的代谢和受体表达及其结肠癌预防意义
Daniel Lechner,Heide S Cross
Daniel Lechner
1alpha,25(OH)2D3 is a potent growth inhibitor of different cancer cell lines. The steroid hormone is not only synthesized in the kidney, but also at extrarenal sites. Unfortunately, this potential autocrine/paracrine defense mechanism is lo...