Stephen Lam,Calum MacAulay,Jean C LeRiche et al.
Stephen Lam et al.
Lung cancer is a major health problem world-wide. Former heavy smokers retain a significant risk for lung cancer after smoking cessation. With a large population of current and former smokers at risk, an alternative cancer control strategy ...
Eva Szabo,Thea Kalebic
Eva Szabo
The refractoriness of advanced lung cancer to current treatment modalities requires new approaches to reduce the public health burden associated with this disease. One strategy that is currently being tested is chemoprevention, which aims t...
Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea [0.03%]
非黑色素瘤皮肤癌的化学预防：绿茶多酚的经验教训
Kenneth G Linden,Philip M Carpenter,Christine E McLaren et al.
Kenneth G Linden et al.
Nonmelanoma skin cancer is extremely common and is increasing in incidence. It would be very useful to have forms of therapy that would prevent precancerous changes from going on to form cancer, or to reverse the precancerous changes. Epide...
Janine G Einspahr,G Timothy Bowden,David S Alberts
Janine G Einspahr
There are over 1 million cases of skin cancer diagnosed yearly in the United States. The majority of these are nonmelanoma (NMSCs) and are associated with chronic exposure to ultraviolet light (UV). Actinic keratosis (AK) has been identifie...
Political interpretation of scientific evidence--case study of breast cancer screening policies around the world [0.03%]
科学证据的政治解读——世界范围乳腺癌筛查政策的案例研究
Gad Rennert
Gad Rennert
Early detection of breast cancer has been studied for effectiveness in reducing mortality for more than four decades. During this period numerous studies took place, with more than half a million participating women. In spite of large amoun...
Stephen A Feig
Stephen A Feig
Substantial reduction in breast cancer mortality has been proven in randomized trials of screening mammography. These trials have found a statistically significant benefit both for women ages 40-49 years and for women age 50 years and older...
Anthony B Miller
Anthony B Miller
The consensus that breast screening is effective for women aged 50-59 years was shattered when Gotzsche and Olsen suggested that there are no reliable data to support screening by mammography. In practice, their concerns have been difficult...
HRT opposed to low-dose tamoxifen (HOT study): rationale and design [0.03%]
雌激素替代疗法对抗小剂量他莫昔芬(HOT研究)：设计和理论依据
Andrea Decensi,Arianna Galli,Umberto Veronesi
Andrea Decensi
The rationale for the HOT study is mainly based on the findings of the Italian Tamoxifen Prevention Study, where 5,408 healthy hysterectomized women aged 35-70 years were randomized to 20 mg/day of tamoxifen or placebo for 5 years. After 81...
Aromatase inhibitors in prevention--data from the ATAC (arimidex, tamoxifen alone or in combination) trial and the design of IBIS-II (the second International Breast Cancer Intervention Study) [0.03%]
aromatase抑制剂在预防中的应用：来自ATAC（阿那曲唑，他莫昔芬或联合使用）试验和IBIS-II（第二个国际乳腺癌干预研究）设计的数据
Jack Cuzick
Jack Cuzick
Current prevention trials have shown that tamoxifen can reduce the incidence of breast cancer by about 30%-40% in high-risk women, but that the risk of thromboembolic disease and endometrial cancer are increased about twofold. An alternativ...
Tamoxifen's impact as a preventive agent in clinical practice and an update on the STAR trial [0.03%]
他莫昔芬临床应用中的预防效果以及Spar试验的后续研究结果更新报告
D Lawrence Wickerham
D Lawrence Wickerham
Tamoxifen has long been an established adjuvant treatment in the management of advanced breast cancer. Studies carried out by the National Surgical Adjuvant Breast and Bowel Project (NSABP) and other groups also established its use in the t...