Pheochromocytoma in MEN2 [0.03%]
MEN2中的嗜铬细胞瘤
Matti L Gild,Kimchi Do,Venessa H M Tsang et al.
Matti L Gild et al.
Pheochromocytomas (PCs) are rare neuroendocrine tumors found in 20-50% of MEN2 patients. MEN2-related PCs are more often bilateral, identified at a younger age and have a low metastatic potential. They secrete epinephrine as the predominant...
Karin Frank-Raue,Friedhelm Raue
Karin Frank-Raue
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant hereditary cancer syndrome caused by germline variants in the REarranged during Transfection (RET) proto-oncogene. MEN2 is caused by autosomal dominant gain-of-function mut...
Yoon Ju Bae,Michael Schaab,Jüergen Kratzsch
Yoon Ju Bae
Calcitonin (CTN) is a polypeptide hormone consisting of 32 amino acids with a disulfide bridge between position 1 and 7 that is mainly produced by the C-cells of thyroid gland. The measurement of CTN concentrations in blood reflects C-cell ...
Stefan Delorme,Friedhelm Raue,Bettina Beuthien-Baumann
Stefan Delorme
Imaging plays an important role in the early detection and staging of medullary thyroid carcinoma (MTC), as well as in follow-up to locate early recurrence. MTC is a rare, calcitonin-secreting thyroid malignancy that is often diagnosed by u...
Epidemiology, Clinical Presentation, and Diagnosis of Medullary Thyroid Carcinoma [0.03%]
髓样甲状腺癌的流行病学、临床表现及诊断
Friedhelm Raue,Karin Frank-Raue
Friedhelm Raue
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from thyroid C cells that produces mainly calcitonin (Ctn) and is used as a tumor marker. MTC can occur either sporadically (75%) or in a hereditary variant (multi...
Rozita Bagheri-Yarmand,Elizabeth G Grubbs,Marie-Claude Hofmann
Rozita Bagheri-Yarmand
The thyroid parafollicular cell, or commonly named "C-cell," functions in serum calcium homeostasis. Elevations in serum calcium trigger release of calcitonin from the C-cell, which in turn functions to inhibit absorption of calcium by the ...
José Manuel Cameselle-Teijeiro,Manuel Sobrinho-Simões
José Manuel Cameselle-Teijeiro
C cells are the neuroendocrine cell component of the thyroid gland that embryologically arise from the pharyngeal endoderm. Normal C cells are concentrated in the upper two-thirds of both lateral lobes, appear singly or in small groups disp...
What Is New in Diagnostics and Management of Medullary Thyroid Carcinoma [0.03%]
甲状腺髓样癌诊断和管理的新进展是什么？
Friedhelm Raue,Karin Frank-Raue
Friedhelm Raue
Medullary thyroid carcinoma (MTC) is a rare neoplasm originating from parafollicular C cells. It secretes calcitonin (Ctn), a highly sensitive and specific tumor marker, which allows for early diagnosis and defines postoperative cure or per...
Narong Khuntikeo,Ross H Andrews,Trevor N Petney et al.
Narong Khuntikeo et al.
Cholangiocarcinoma (CCA) is the second most common primary liver cancer worldwide. Despite the severity of the disease and its impact on individuals, families, and communities, there remains an overall lack of awareness and interest in this...
Helen Morement,Narong Khuntikeo
Helen Morement
Although cholangiocarcinoma (CCA) or bile duct cancer is considered rare, worldwide it is the second most common primary liver cancer. The incidence is increasing globally, and mortality is high owing to its aggressiveness, late diagnosis, ...