Pauline Gilson
Pauline Gilson
ctDNA provided by liquid biopsy offers a promising alternative to tumor biopsy as it gives a non-invasive and «real-time» access to the cancer genome and reflects tumor intra and extra heterogeneity. ctDNA has shown growing clinical inter...
Pathophysiology of ctDNA Release into the Circulation and Its Characteristics: What Is Important for Clinical Applications [0.03%]
循环肿瘤DNA释放的发病机制及其临床应用的重要特征
Nickolas Papadopoulos
Nickolas Papadopoulos
The clinical implications of being able to accurately detect tumor-derived DNA in the circulation, termed circulating tumor DNA (ctDNA), could be enormous. Already, a plethora of clinical applications is under validation that include detect...
Erin F Cobain,Costanza Paoletti,Jeffrey B Smerage et al.
Erin F Cobain et al.
The development of metastatic disease accounts for the vast majority of cancer-related deaths in solid tumor malignancies. Distant metastases primarily develop as a result of tumor cell dissemination through the circulatory system. ...
Diana H Liang,Carolyn Hall,Anthony Lucci
Diana H Liang
With active screening for early detection and advancements in treatment, there has been a significant decrease in mortality from breast cancer. However, a significant proportion of patients with non-metastatic breast cancer at time of diagn...
Francesca Chemi,Sumitra Mohan,Ged Brady
Francesca Chemi
Circulating tumour cells (CTCs) constitute a potential tumour surrogate that could serve as "liquid biopsy" with the advantage to be a minimally invasive approach compared to traditional tissue biopsies. As CTCs are thought to be the source...
Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis [0.03%]
循环肿瘤细胞的高通量影像及生物信息分析
Kevin Keomanee-Dizon,Stephanie N Shishido,Peter Kuhn
Kevin Keomanee-Dizon
Circulating tumor cells (CTCs) represent novel biomarkers, since they are obtainable through a simple and noninvasive blood draw or liquid biopsy. Here, we review the high-definition single-cell analysis (HD-SCA) workflow, which brings toge...
Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring [0.03%]
基于RNA的数字评分法量化分析循环肿瘤细胞
Mark Kalinich,Tanya T Kwan,Mehmet Toner et al.
Mark Kalinich et al.
Circulating tumor cells (CTCs) provide valuable information about the molecular evolution of cancers, as they may initially respond and ultimately progress on therapy. As intact tumor cells isolated from the bloodstream, CTCs also enable as...
Michael Paul Kolinsky,Nikolas Stoecklein,Maryou Lambros et al.
Michael Paul Kolinsky et al.
The classification of human cancers has traditionally relied on the tissue of origin, the histologic appearance and anatomical extent of disease, otherwise referred to as grade and stage. However, this system fails to explain the highly var...
Mert Boya,Chia-Heng Chu,Ruxiu Liu et al.
Mert Boya et al.
Circulating tumor cells (CTCs) are responsible for the metastatic spread of cancer and therefore are extremely valuable not only for basic research on cancer metastasis but also as potential biomarkers in diagnosing and managing cancer in t...
Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC [0.03%]
肿瘤细胞入血的病理生理及CTC的表征研究进展
Tilman Todenhöfer,Klaus Pantel,Arnulf Stenzl et al.
Tilman Todenhöfer et al.
The traditional model of metastatic progression postulates that the ability to form distant metastases is driven by random mutations in cells of the primary tumor.