Hendrik Seeliger,Hanno Spatz,Karl-Walter Jauch
Hendrik Seeliger
In curatively resected gastric cancer, the incidence of distant relapse is as high as 30%. Although the most important factor contributing to the local control of the tumor is the microscopic tumor-free margin of the surgical resection, the...
Clinical implications of molecular diagnosis in hereditary nonpolyposis colorectal cancer [0.03%]
遗传性非息肉病性大肠癌的分子诊断的意义
Gabriela Möslein
Gabriela Möslein
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary cancer predisposition accounting for approximately 1%-5% of all colorectal cancers. Clinical management of HNPCC families is most challenging due to the following factors: (1...
Heinz Höfler,Karl-Friedrich Becker
Heinz Höfler
The catalog of gene alterations in human cancer grows rapidly. Gastric cancer is no exception and displays gene changes in multiple oncogenes, suppressor genes, and DNA repair genes. Clinically relevant molecules whose expression or structu...
Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo [0.03%]
肿瘤相关尿激酶型纤溶活化系统的抑制：体内外卵巢癌和乳腺癌细胞中可溶性尿激酶受体的高效合成的影响
Viktor Magdolen,Achim Krüger,Sumito Sato et al.
Viktor Magdolen et al.
Tumor cell invasion and metastasis depend on the coordinated and temporal expression of proteolytic enzymes to degrade the surrounding extracellular matrix and of adhesion molecules to remodel cell-cell and/or cell-matrix attachments. The t...
Kasper Almholt,Morten Johnsen
Kasper Almholt
Solid tumors co-opt the body's endogenous extracellular proteolytic machinery for their invasion and metastasis. This is supported by a large number of independent observations ranging from histochemical and prognostic studies of cancer pat...
Molecular regulation of urokinase-receptor gene expression as one potential concept for molecular staging and therapy [0.03%]
尿激酶受体基因表达的分子调控是一项潜在的分子分期和治疗概念
Heike Allgayer
Heike Allgayer
The urokinase-receptor (u-PAR) is a central molecule of invasion and metastasis promoting plasminogen-dependent extracellular matrix degradation in diverse carcinoma types such as gastric or colon cancer. Overexpression of u-PAR has been re...
The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction [0.03%]
尿激酶受体（uPAR，CD87）作为肿瘤治疗的靶点：uPA-硅颗粒（SP-uPA）作为一种新的工具来评估用于干扰uPA/uPA受体相互作用的人工肽
Elke Guthaus,Niko Schmiedeberg,Markus Bürgle et al.
Elke Guthaus et al.
Many different processes in the physiology and pathophysiology of human beings are regulated protein/protein interactions such as receptor/ligand interactions. A more detailed knowledge of the nature of receptor/ligand binding sites and mec...
Tetsuro Kubota,Yoshihide Otani,Toshiharu Furukawa et al.
Tetsuro Kubota et al.
Radical surgery with extended lymph node dissection is the first and only curative treatment of gastrointestinal cancer. Although the combined cancer chemotherapy has achieved 30%-50% response rates, a controversy still remains over the sig...
ATP chemosensitivity testing in ovarian and breast cancer: early clinical trials [0.03%]
卵巢癌和乳腺癌的阿特普化学敏感性检验：临床早期试验结果
Christian M Kurbacher,Ottilia M Grecu,Ursula Stier et al.
Christian M Kurbacher et al.
After disappointing results achieved with older chemosensitivity tests such as the human tumor clonogenic assay (HTCA) during the 1980s, the last decade has seen a renaissance of the concept of individualized chemotherapy in oncology, marke...
G J L Kaspers,A J P Veerman
G J L Kaspers
Cellular drug resistance is an important determinant of the response to chemotherapy, and its precise measurement may have clinical relevance. Potential applications are: prognostic factor for risk-group stratification, tailored chemotherap...