Adrian Stecula,Rebecca Paul,Kevin Litchfield et al.
Adrian Stecula et al.
The arrival of AlphaFold marked a new era in structural biology, with this transformative AI technology now reshaping the landscape of drug design. In this chapter we discuss advances across the drug design process, including target identif...
Drug design strategies for the selective targeting of lung, liver and kidney [0.03%]
针对肺、肝和肾的特异性药物设计策略
Mafalda Pagano,Claudia Beato,Agostino Cianciulli et al.
Mafalda Pagano et al.
The selective targeting of lung, liver, and kidney tissues presents both a significant challenge and a promising opportunity in medicinal chemistry. This review explores drug design strategies aimed at achieving tissue specificity, using de...
To homeostasis and beyond! Recent advances in the medicinal chemistry of heterobifunctional derivatives [0.03%]
从稳态到更远！杂双功能衍生物药物化学的最新进展
Diana Castagna,Benoit Gourdet,Roland Hjerpe et al.
Diana Castagna et al.
The field of induced proximity therapeutics has expanded dramatically over the past 3 years, and heterobifunctional derivatives continue to form a significant component of the activities in this field. Here, we review recent advances in the...
Another decade of antimalarial drug discovery: New targets, tools and molecules [0.03%]
疟原虫抗疟药物发现的十年：新靶点、工具和化合物
John G Woodland,André Horatscheck,Candice Soares de Melo et al.
John G Woodland et al.
Malaria remains a devastating but preventable infectious disease that disproportionately affects the African continent. Emerging resistance to current frontline therapies means that not only are new treatments urgently required, but also no...
Praful Chovatia,Angelo Sanzone,Gert-Jan Hofman et al.
Praful Chovatia et al.
This review article explores the pivotal role of conformational drivers in the discovery of drug-like molecules and illustrates their significance through real-life examples. Understanding molecular conformation is paramount to drug hunting...
Jonathan Bentley,Matilda Bingham
Jonathan Bentley
Matilda Bingham,Thomas Pesnot,Andrew D Scott
Matilda Bingham
In the last two decades the use of biophysical assays and methods in medicinal chemistry has increased significantly, to meet the demands of the novel targets and modalities that drug discoverers are looking to tackle. The desire to obtain ...
Covalent fragment libraries in drug discovery-Design, synthesis, and screening methods [0.03%]
药物发现中的共价片段库设计、合成及筛选方法
Brad Hocking,Alan Armstrong,David J Mann
Brad Hocking
As the development of drugs with a covalent mode of action is becoming increasingly popular, well-validated covalent fragment-based drug discovery (FBDD) methods have been comparatively slow to keep up with the demand. In this chapter the p...
Adrian D Hobson
Adrian D Hobson
For many years, antibody drug conjugates (ADC) have teased with the promise of targeted payload delivery to diseased cells, embracing the targeting of the antibody to which a cytotoxic payload is conjugated. During the past decade this prom...