The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy [0.03%]
帕金森病、多系统萎缩和进行性核上性麻痹的昼夜节律系统
Karim Fifel,Tom De Boer
Karim Fifel
Circadian organization of physiology and behavior is an important biologic process that allows organisms to anticipate and prepare for predictable changes in the environment. Circadian disruptions are associated with a wide range of health ...
Dick F Swaab,Ruud M Buijs,Felix Kreier et al.
Dick F Swaab et al.
Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities [0.03%]
阿尔茨海默病的昼夜节律变化：神经生物学、临床问题和治疗机会
Karlo Toljan,Jan Homolak
Karlo Toljan
The understanding of Alzheimer's disease (AD) pathophysiology is an active area of research, and the traditional focus on hippocampus, amyloid and tau protein, and memory impairment has been expanded with components like neuroinflammation, ...
Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease [0.03%]
人类大脑中的昼夜节律和季节性分子节律及其与阿尔茨海默病的关系
Andrew S P Lim
Andrew S P Lim
Diurnal and seasonal rhythms influence many aspects of human physiology including brain function. Moreover, altered diurnal and seasonal behavioral and physiological rhythms have been linked to Alzheimer's disease and related dementias (ADR...
William H Walker nd,James C Walton,Randy J Nelson
William H Walker nd
During the evolution of life, the temporal rhythm of our rotating planet was internalized in the form of circadian rhythms. Circadian rhythms are ~24h internal manifestations that drive daily patterns of physiology and behavior. These rhyth...
Development of the circadian system and relevance of periodic signals for neonatal development [0.03%]
昼夜节律系统的发育及周期性信号对新生儿发育的意义
Carolina Escobar,Adelina Rojas-Granados,Manuel Angeles-Castellanos
Carolina Escobar
Circadian rhythms are generated endogenously with a period of approximately 24h. Studies carried out during the last decade indicate that the circadian system develops before birth, and that the suprachiasmatic nucleus, a structure that is ...
Ruud M Buijs,Eva C Soto Tinoco,Gabriela Hurtado Alvarado et al.
Ruud M Buijs et al.
The circadian system, composed of the central autonomous clock, the suprachiasmatic nucleus (SCN), and systems of the body that follow the signals of the SCN, continuously change the homeostatic set points of the body over the day-night cyc...
Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease [0.03%]
阿尔茨海默病基底前脑胆碱能神经元梅耶尔核的基因和细胞治疗与NGF疗法
Maria Eriksdotter,Sumonto Mitra
Maria Eriksdotter
There is currently no effective treatment for the most common of the dementia disorders, Alzheimer's disease (AD). It has been known for decades that the central cholinergic system is important for memory. The cholinergic neurons in the bas...
Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease [0.03%]
阿尔茨海默病中胆碱能神经元早期内体增大及基底前脑中交通堵塞现象
Atoossa Fahimi,Mahjabin Noroozi,Ahmad Salehi
Atoossa Fahimi
While a handful of neurotransmitter systems including cholinergic, norepinephrinergic, and serotonergic undergo significant degeneration in Alzheimer's disease, the cholinergic system has been the prime target for research and therapy. The ...
Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease [0.03%]
梅耶尔基底核变性预示帕金森病认知障碍发生
Heather Wilson,Edoardo Rosario de Natale,Marios Politis
Heather Wilson
Cognitive impairment affects approximately 20%-50% of patients with Parkinson's disease (PD), with a higher prevalence as the disease advances. The nucleus basalis of Meynert (NBM) provides the majority of cholinergic innervations to the ce...