Elena G Bochukova
Elena G Bochukova
Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, arising from a loss of paternity expressed genetic material on the imprinted chromosome locus 15q11-q13. Despite increasing clarity on the underlying genetic defects, the...
Maithé Tauber,Gwenaelle Diene
Maithé Tauber
Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental disorder linked to the lack of expression of specific maternally imprinted genes located in the chromosomal region 15q11-q13. Impaired hypothalamic development and function ex...
Hypothalamus and neuroendocrine diseases: The use of human-induced pluripotent stem cells for disease modeling [0.03%]
下丘脑与神经内分泌疾病：用于疾病建模的人类诱导多能干细胞的应用
Roberta de Souza Santos,Andrew R Gross,Dhruv Sareen
Roberta de Souza Santos
The hypothalamus, which is part of the brain of all vertebrate animals, is considered the link between the central nervous system (CNS) and (i) the endocrine system via the pituitary gland and (ii) with our organs via the autonomic nervous ...
Anna Maria van Opstal
Anna Maria van Opstal
Energy balance is centrally regulated by the brain through several interacting neuronal systems involving external, peripheral, and central factors within the brain. The hypothalamus integrates these factors and is the key brain area in the...
Dongsheng Cai,Sinan Khor
Dongsheng Cai
Over the past decade, hypothalamic microinflammation has been studied and appreciated as a core mechanism involved in the advancement of metabolic syndrome and aging. Accumulating evidence suggests that atypical microinflammatory insults di...
I Sadaf Farooqi
I Sadaf Farooqi
Neural circuits in the hypothalamus play a key role in the regulation of human energy homeostasis. A critical circuit involves leptin-responsive neurons in the hypothalamic arcuate nucleus (the infundibular nucleus in humans) expressing the...
Sabrina Chiloiro,Antonella Giampietro,Antonio Bianchi et al.
Sabrina Chiloiro et al.
Empty sella is a pituitary disorder characterized by the herniation of the subarachnoid space within the sella turcica. This is often associated with a variable degree of flattening of the pituitary gland. Empty sella has to be distinguishe...
Konstantinos Kamperis
Konstantinos Kamperis
Nocturnal enuresis is the involuntary pass of urine during sleep beyond the age of 5 years. It is a common condition in childhood and has an impact on the child's well-being. Research into the pathophysiology of the condition in the last de...
Javier Mahía,Antonio Bernal
Javier Mahía
The hormone arginine vasopressin (AVP) is a nonapeptide synthesized by hypothalamic magnocellular nuclei and secreted from the posterior pituitary into the bloodstream. It binds to AVP receptor 2 in the kidney to promote the insertion of aq...
Adipsic diabetes insipidus [0.03%]
无渴症性尿崩症
Vallari Kothari,Zulma Cardona,Yuval Eisenberg
Vallari Kothari
Adipsic diabetes insipidus (ADI) is a rare but devastating disorder of water balance with significant associated morbidity and mortality. Most patients develop the disease as a result of hypothalamic destruction from a variety of underlying...