Role of B cells and pathogenic autoantibodies in autoimmune CNS and PNS neurologic diseases [0.03%]
自身免疫性中枢神经系统和周围神经系统的自身抗体和致病自身抗抗体的作用
Panos Stathopoulos,Marinos C Dalakas
Panos Stathopoulos
B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurologic disorders, acting, in addition to their autoantibody-secreting role, as antigen-presenting cells but also as sensors, coordinators, and regulator...
The future unfolded: CAR T cells and the transformation of treatment algorithms in autoimmune neurology [0.03%]
未来已来：CAR-T细胞和自身免疫性神经系统疾病的治疗算法的变革
Dimitrios Mougiakakos,Marinos C Dalakas
Dimitrios Mougiakakos
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematologic malignancies, and its application in neuroimmunologic autoimmune diseases is now emerging as a promising therapeutic avenue. Neuroimmunologic dis...
Immunotherapies in autoimmune inflammatory myopathies: Rationale and therapeutic updates [0.03%]
自身免疫性炎性肌病的免疫疗法：理据及治疗更新
Goran Rakocevic,Marinos C Dalakas
Goran Rakocevic
Autoimmune inflammatory myopathies (AIM) constitute a heterogeneous group of acquired myopathies with endomysial inflammation as a shared feature highlighting a potentially autoimmune inflammatory process amenable to immunotherapies. The di...
Immunotherapies in autoimmune neuromuscular junction disorders: Acute and chronic management [0.03%]
自身免疫性神经肌肉接头疾病的免疫疗法：急性期和慢性期的管理
Amelia Evoli,Nils Erik Gilhus,Donald B Sanders
Amelia Evoli
Myasthenia gravis (MG) is the most common disease of the neuromuscular junction. Conventional immunotherapy based on corticosteroids and immunosuppressants has been in use for several decades and has greatly contributed to the improvement o...
Immunotherapy considerations for distal sensory-predominant and small-fiber peripheral neuropathies [0.03%]
远端感觉性为主和小纤维周围神经病变的免疫疗法考虑事项
Anne Louise Oaklander
Anne Louise Oaklander
Increasing knowledge about the common widespread, distal-predominant polyneuropathies is shifting the standard of care beyond merely palliating symptom toward intervention. This is less advanced for the more prevalent but harder-to-ascertai...
Brent P Goodman
Brent P Goodman
Autoimmune autonomic disorders are common, though often under-recognized, and suboptimally understood. Autonomic nervous system impairment may result from immune-mediated damage to central or peripheral autonomic pathways, and typically inv...
Chiara Briani,Andrea Visentin
Chiara Briani
Steroids and immunoglobulins, either intravenous or subcutaneous, have represented the cornerstone treatment of chronic immune-mediated neuropathies for many years. In the last decade, new therapeutic targets are being studied, with the pot...
Immunotherapies on Guillain-Barré syndrome and other acute autoimmune neuropathies [0.03%]
特发性炎症性神经病的免疫治疗
Linda W G Luijten,Bart C Jacobs
Linda W G Luijten
Guillain-Barré syndrome (GBS) and other acute autoimmune neuropathies are rare but severe immune-mediated diseases of the peripheral nervous system. Early diagnosis is important for adequate monitoring and treatment, but it can be complica...
Immunobiology and immunotherapies in stiff-person syndrome and glutamic acid decarboxylase antibody-spectrum disorders: Present and future therapeutic prospects [0.03%]
僵人综合征和谷氨酸脱羧酶自身抗体谱系病的免疫生物学及免疫治疗：目前及未来的治疗前景
Marinos C Dalakas
Marinos C Dalakas
Stiff-person syndrome (SPS) is increasingly recognized as the prototypic and most common autoimmune neuronal hyperexcitability disorder that presents with stiffness in the limbs and axial muscles, stiff gait with uncontrolled falls, and epi...
Progress of neuroimmunotherapies: Witnessing an impressive success in the treatment of neurologic autoimmunities [0.03%]
神经免疫疗法的进展：见证治疗神经系统自身免疫疾病的显著成功
Marinos C Dalakas
Marinos C Dalakas
This introductory chapter describes the evolution of immunotherapies in neurology as witnessed from the late 1970s to early 1980s, when the main therapy for all autoimmune neurologic diseases was only oral and IV steroids, to the present. T...