Felix F L Reichel,Julia-Sophia Bellingrath,Peter Kiraly et al.
Felix F L Reichel et al.
Gene therapy is being investigated as a potential treatment for a range of inherited and acquired retinal diseases. This chapter provides an overview of current gene therapy strategies, including gene augmentation and gene editing approache...
Tristan T Hormel,Yali Jia
Tristan T Hormel
Optical coherence tomography (OCT) has become an indispensable ophthalmic imaging modality in both research and clinical practice due to its ability to noninvasively provide volumetric imaging of the retina at high resolution. However, desp...
Bryan William Jones
Bryan William Jones
The retina is a highly organized sensory structure responsible for capturing and processing visual information. Visual computation begins at the first synapse between photoreceptors, bipolar cells, and horizontal cells, before involving ama...
Minzhong Yu,Emile R Vieta-Ferrer,Xiaoyan Ding
Minzhong Yu
This chapter delves into various genetic pathways associated with inherited retinal diseases (IRDs). It discusses the heterogeneity within this group of disorders and the importance of understanding the genetic landscape to identify underly...
James P Winebrake,Jennifer I Lim
James P Winebrake
The retina, uniquely accessible as an extension of the central nervous system, plays a critical role in neurology and ophthalmology. Advances in retinal imaging technologies - including color fundus photography, optical coherence tomography...
Yannik Laich,Michalis Georgiou,Michel Michaelides
Yannik Laich
Stargardt macular dystrophy (STGD1) is the most prevalent inherited macular dystrophy, characterized by progressive central vision loss and decline of visual acuity. It is caused by homozygous or compound heterozygous variants in the ABCA4 ...
Retinal vein occlusion [0.03%]
视网膜静脉阻塞
Tahreem A Mir,Ingrid U Scott,Stephen J Kim
Tahreem A Mir
Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy and can result in significant vision loss and ocular morbidity. Vision loss may result from hemorrhages, macular ischemia (if there i...
Étienne Bénard-Séguin,Brian Mac Grory,Nancy J Newman et al.
Étienne Bénard-Séguin et al.
Acute retinal artery occlusions present with sudden, painless monocular vision loss and are equivalent to cerebral strokes. The diagnosis is made on ocular fundus examination facilitated by fundus photography and optical coherence tomograph...
Francine Behar-Cohen,Alexandre Matet,Alejandra Daruich
Francine Behar-Cohen
Retinal detachment (RD) occurs when the neurosensory retina separates from the retinal pigment epithelium (RPE). The most frequent type, rhegmatogenous retinal detachment (RRD), is caused by full-thickness retinal breaks that typically aris...
Henry Bair,Mak Djulbegovic,Joel S Schuman
Henry Bair
Glaucoma, a prevalent cause of blindness, refers to a group of optic neuropathies that result in the degeneration of retinal ganglion cells. Glaucoma can be broadly classified based on the anatomy of the anterior chamber angle (open vs clos...