Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins [0.03%]
磷脂转移蛋白介导的磷脂酰肌醇转运
Shamshad Cockcroft
Shamshad Cockcroft
PtdIns is synthesized at the endoplasmic reticulum and its intracellular distribution to other organelles can be facilitated by lipid transfer proteins [PITPs (phosphatidylinositol transfer proteins)]. In this review, I summarize the curren...
Regulation of phospholipase D activity, membrane targeting and intracellular trafficking by phosphoinositides [0.03%]
磷脂酰肌醇对磷脂酶D活性、膜定位和细胞内转运的调节作用
Andrew J Morris
Andrew J Morris
Generation of PA (phosphatidic acid) by PLD (phospholipase D)-catalysed hydrolysis of phosphatidylcholine plays a pivotal role in cellular signalling pathways that regulate organization of the actin cytoskeleton, vesicular transport and exo...
Robert H Michell
Robert H Michell
Several of the nine hexahydroxycylohexanes (inositols) have functions in Biology, with myo-inositol (Ins) in most of the starring roles; and Ins polyphosphates are amongst the most abundant organic phosphate constituents on Earth. Many Arch...
Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates') [0.03%]
理解二磷肌醇多磷酸盐（“肌醇焦磷酸盐”）的生物学意义
Stephen B Shears
Stephen B Shears
Among the many derivatives of the inositol-based signalling family are a subgroup that possess diphosphates. In this review, some recent research into the actions of these specialized polyphosphates is analysed, and key goals for future stu...
Multiple functions of inositolphosphorylceramides in the formation and intracellular transport of glycosylphosphatidylinositol-anchored proteins in yeast [0.03%]
酵母中糖基磷脂酰肌醇锚定蛋白形成及胞内运输的联膦肌醇 ceramide 的多种功能
Régine Bosson,Andreas Conzelmann
Régine Bosson
The mature sphingolipids of yeast consist of IPCs (inositolphosphorylceramides) and glycosylated derivatives thereof. Beyond being an abundant membrane constituent in the organelles of the secretory pathway, IPCs are also used to constitute...
Andrew M Seeds,John D York
Andrew M Seeds
Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. Th...
The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors? [0.03%]
肌醇磷酸酯五磷酸酶：交通控制器，腰围观察者和肿瘤抑制剂？
Megan V Astle,Kristy A Horan,Lisa M Ooms et al.
Megan V Astle et al.
Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3, by inositol polyphosphate 5-phosphatases regulates synaptic ve...
Jonathan H Clarke,Jonathan P Richardson,Katherine A Hinchliffe et al.
Jonathan H Clarke et al.
The regulation of the synthesis of PtdIns(4,5)P2 is emerging as being as complex as we might expect from the multi-functional nature of this lipid. In the present chapter we focus on one aspect of inositide metabolism, which is the function...
Vojo Deretic,Sudha Singh,Sharon Master et al.
Vojo Deretic et al.
Interconversions of phosphoinositides play a pivotal role during phagocytosis and at the subsequent stages of phagosomal maturation into the phagolysosome. Several model systems have been used to study the role of phosphoinositides in phago...