Bradford C Berk
Bradford C Berk
Reduction-oxidation (redox) reactions that generate reactive oxygen species (ROS) such as hydrogen peroxide and superoxide have been identified as important chemical processes that regulate signal transduction. The findings of increased ROS...
J Gregory Fitz
J Gregory Fitz
Epithelial cells exhibit regulated release of ATP. Once outside of the cell, ATP in nanomolar concentrations functions as an autocrine/paracrine signal modulating a broad range of cell and organ functions through activation of purinergic re...
Patrick T O&#x;Gara
Patrick T O&#x;Gara
Infective endocarditis has challenged clinicians for centuries. Despite recent advances in diagnosis and therapy, the risks of major complications and death in many clinical situations remain unacceptably high, related in part to patient de...
Lessons about the pathogenesis and management of aspergillosis from studies in chronic granulomatous disease [0.03%]
慢性肉芽肿病研究中的曲霉菌感染发病机制和治疗经验教训
John I Gallin,Kol Zarember
John I Gallin
Chronic Granulomatous Disease (CGD) is a rare disorder caused by mutations in the NADPH oxidase. The CGD phenotype includes granuloma formation and susceptibility to infection with microorganisms including Aspergillus. The immune adjuvant i...
Nigel S Key,Jian-Guo Geng,Ronald R Bach
Nigel S Key
Tissue factor is the principal activator of blood coagulation in vivo. The existence of extravascular tissue factor has been recognized for over a century, but a rational role as a cell-based enzymatic cofactor in blood coagulation was firs...
Cardiac resynchronization therapy: can we make our heart failure patients smarter? [0.03%]
心脏再同步治疗：如何让心力衰竭患者受益？
Jamie B Conti,Samuel F Sears
Jamie B Conti
Patients with congestive heart failure have impaired cognitive function, possibly caused by impaired global and regional cerebral blood flow. We hypothesized that biventricular pacing-simultaneous activation of the both the septum and the l...
The Gordon Wilson Lecture: neurohormonal signaling pathways that link cardiac growth and death [0.03%]
Gordon Wilson 讲座：连接心脏生长和死亡的神经激素信号通路
Gerald W Dorn
Gerald W Dorn
Far from being a simple muscular pump, the heart senses changes in hemodynamic forces and neurohormonal signaling, and responds by elaborating autocrine and paracrine factors that self-regulate cardiomyocyte contraction, growth, and program...
Kelley M Skeff
Kelley M Skeff
The process of teaching is ubiquitous in medicine, both in the practice of medicine and the promotion of medical science. Yet, until the last 50 years, the process of medical teaching had been neglected. To improve this process, the researc...
Theodore E. Woodward Award: spare me the PowerPoint and bring back the medical textbook [0.03%]
Woodward奖获奖感言：省省您的PPT吧，把医学教材带回来吧
Frederick S Southwick
Frederick S Southwick
A tutorial for 4(th) year medical students revealed absent long-term retention of microbiology and infectious disease facts taught during the 2(nd) year. Students were suffering from the Ziegarnik effect, the loss of memory after completion...
Theodore E. Woodward Award: antiphospholipid syndrome revisited: a disorder initiated by inflammation [0.03%]
Woodward奖获奖论文：抗磷脂综合征的再思考：一种由炎症引发的疾病
Jane E Salmon,Guillermina Girardi
Jane E Salmon
The antiphospholipid syndrome (APS), characterized by thrombosis and pregnancy loss that occur in the presence of antiphospholipid (aPL) antibodies, is a leading cause of miscarriage and maternal and fetal morbidity. Using a mouse model of ...