Kevin P High
Kevin P High
Aging is a recent development in human history with nearly half of all median life expectancy gains occurring in the last two to three centuries. Aging is the strongest risk factor for medical conditions that predominately account for morbi...
TESTOSTERONE AND INSULIN RESISTANCE IN MEN: EVIDENCE FOR A COMPLEX BI-DIRECTIONAL RELATIONSHIP [0.03%]
睾酮与男性胰岛素抵抗之间的关系：相互作用的证据
Frances J Hayes
Frances J Hayes
Given that low testosterone levels predict type 2 diabetes mellitus (T2DM) in men, we sought to dissect the relationship between testosterone and insulin sensitivity in men. We showed a positive correlation between serum testosterone levels...
David A D&#x;Alessio
David A D&#x;Alessio
Traditionally, the islet hormone glucagon has been considered as a counterbalance to insulin, preventing hypoglycemia by promoting glucose release from the liver. This model is compatible both with clinical studies demonstrating that one of...
IMPLEMENTING HOME-BASED CANCER PREVENTION AND SCREENING: AN OPPORTUNITY FOR EQUITY [0.03%]
基于家庭的癌症预防和筛查措施落地实施——促进公平的机会
Michael Pignone
Michael Pignone
Cancer remains a leading cause of mortality in the United States, with significant inequities across racial and ethnic groups. Evidence-based cancer screening and prevention offers one pathway to reducing cancer mortality but can be challen...
THE BERT AND PEGGY DUPONT LECTURE: FROM EARTH TO MARS: THE LIFE OF MARS 2020'S PERSEVERANCE ROVER [0.03%]
从地球到火星：2020年“毅力”号漫游车的使命之旅
Bekah Sosland Siegfriedt
Bekah Sosland Siegfriedt
THE GID COMPLEX REGULATES DNA END PROCESSING DURING DNA DOUBLE-STRAND BREAK REPAIR BY NONHOMOLOGOUS END JOINING [0.03%]
gid复合体通过非同源末端连接修复双链DNA断裂过程中调节DNA末端处理
Barry P Sleckman,Bo-Ruei Chen
Barry P Sleckman
Genome instability is a hallmark of cancer, allowing for clonal evolution and improved tumor fitness. The mis-repair of DNA double-strand breaks (DSBs) is a major source of genome instability. DNA DSBs are normally repaired by homologous re...
Paul B McCray
Paul B McCray
A critical adaptation required for successful extrauterine life is the onset of respiration. The production of pulmonary surfactant by alveolar type II (AT2) cells is required for functional ventilation. Pulmonary surfactant is produced in ...
Kelly E Dooley,Radojka Savic
Kelly E Dooley
Today's first-line tuberculosis regimen was developed in the 1950s to 1970s, followed by a long period of stagnation. New drugs have progressed to market only recently, with long timelines from target discovery to clinical trial success, al...
Chi V Dang
Chi V Dang
Otto Warburg sparked the field of cancer metabolism in the 1920s through his observations that human and animal cancer tissues converted significant amounts of glucose to lactate with an elusive underlying mechanism. The discovery of oncoge...