Having a change of heart: reversing the suicidal proclivities of cardiac myocytes [0.03%]
换个心情：逆转心肌细胞的自杀倾向
Gerald W Dorn nd
Gerald W Dorn nd
The molecular and cellular basis for cardiac remodeling have been difficult to establish. Transcriptional analysis and genetic manipulation of the mouse heart have revealed expression of a molecular program for cardiac myocyte suicide under...
Theodore E. Woodward Award: Coming in out of the rain. Relieving congestion in heart failure [0.03%]
Woodward奖获奖论文：拨云见日。寻找心力衰竭的解决之道
Lynne Warner Stevenson;ESCAPE and COMPASS trials
Lynne Warner Stevenson;ESCAPE and COMPASS trials
Heart failure decompensation is dominated by congestive symptoms from elevated pulmonary and systemic venous pressures. In dilated heart failure, forward flow is optimal at near-normal filling pressures, with minimized mitral regurgitation....
Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels [0.03%]
他汀类和依折麦布调节血浆前蛋白转化酶枯草杆菌肽kexin 9(PCSK9)水平
Jean Davignon,Geneviève Dubuc
Jean Davignon
PCSK9 is a natural inhibitor of the LDL receptor. Gain-of-function mutations may cause the familial hypercholesterolemia phenotype, whereas loss-of-function variants associate with reduced LDL-C levels and lower coronary risk. Statins up-re...
Michael J Welsh,Christopher S Rogers,David A Stoltz et al.
Michael J Welsh et al.
Cystic Fibrosis (CF) is a common autosomal recessive disease that affects multiple organs. The lack of an animal model with manifestations like those typically found in humans has slowed understanding of its pathogenesis. Therefore, because...
Comparative Study
Transactions of the American Clinical and Climatological Association. 2009:120:149-62. DOI: 2009
François M Abboud
François M Abboud
Global climate change and health: developing a research agenda for the NIH [0.03%]
全球气候变化与健康：NIH研究日程的制定
Joshua P Rosenthal,Christine M Jessup
Joshua P Rosenthal
Global climate change is receiving worldwide attention because of its anticipated impacts on the Earth's physical and biological systems. Through its effects on natural and human environments, climate change will likely impact economic viab...
Guillaume Constantin de Magny,Rita R Colwell
Guillaume Constantin de Magny
Vibrio cholerae, the causative agent of cholera, is naturally present in the environment and autochthonous to coastal and estuarine ecosystems. V. cholerae is associated with copepods for its survival and multiplication in the natural envir...
George Luber,Natasha Prudent
George Luber
Climate change science points to an increase in sea surface temperature, increases in the severity of extreme weather events, declining air quality, and destabilizing natural systems due to increases in greenhouse gas emissions. The direct ...
Donald A B Lindberg,Sally E Howe
Donald A B Lindberg
Why did the founders of this organization-which was established in 1884 as the American Climatological Association-want to study climatology and respiratory diseases? In particular, where did the idea of treating tuberculosis with pure air ...