David A Brenner
David A Brenner
Hepatic fibrosis is the final common pathway for most chronic liver diseases. The cell responsible for hepatic fibrosis appears to be the activated myofibroblast. The myofibroblast may be derived from quiescent hepatic stellate cells, epith...
The Jeremiah Metzger Lecture: gene therapy for inherited disorders: from Christmas disease to Leber's amaurosis [0.03%]
耶利米·梅茨格演讲：遗传病的基因治疗：从圣诞病到莱伯先天性黑蒙
Katherine A High
Katherine A High
This paper will focus on recent developments in the field of gene therapy for inherited disorders. From a historical perspective, this Metzger lecture is a follow-on to one presented by Dr. William Kelley in 1987, entitled "Current Status o...
François M Abboud
François M Abboud
Donald A Gurnett
Donald A Gurnett
In this presentation I give an overview of the long struggle to answer the age old question, does life exist anywhere else? The focus will be specifically on the search for life in the solar system, since this is the only region currently a...
François M Abboud
François M Abboud
Do the obese have lower body temperatures? A new look at a forgotten variable in energy balance [0.03%]
肥胖者体温较低吗？能量平衡中一个被遗忘变量的再思考
Lewis Landsberg,James B Young,William R Leonard et al.
Lewis Landsberg et al.
Understanding the pathogenesis of obesity is now more important than ever, given the remarkable world-wide epidemic. This paper explores the potential role of core temperature in energy balance, and develops the hypothesis that basal temper...
Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession [0.03%]
睡眠不足对表现产生不利影响的医学和遗传差异：医疗职业的伦理考虑因素
Charles A Czeisler
Charles A Czeisler
The Institute of Medicine recently concluded that-on average-medical residents make more serious medical errors and have more motor vehicle crashes when they are deprived of sleep. In the interest of public safety, society has required limi...
Steven Weinberger
Steven Weinberger
Academic faculty involved in medical education are set apart from educators in other fields by a different set of expectations and responsibilities. For a subgroup of such faculty, classified in this paper as clinician educators and educati...
New medical schools in the United States: forces of change past and present [0.03%]
美国的新医学院：过去和现在的变革力量
Lawrence Smith
Lawrence Smith
The new millennium has ushered in a growth phase in the number of American medical schools. Historically the United States has built schools during bursts of activity with relative quiescence in between these periods. We had a twenty-two ye...
Portraits of an illness [0.03%]
疾病的画像
Thomas P Duffy
Thomas P Duffy
Access to patients' inner lives can be expanded and enriched by incorporating the arts and humanities into the clinical encounter. A series of self-portraits created by an artist undergoing induction chemotherapy for leukemia afforded a uni...