ALTERATIONS IN HISTIDINE METABOLISM IS A FEATURE OF EARLY AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) [0.03%]
组氨酸代谢的改变是常染色体显性多囊肾病(ADPKD)早期的一个特征
Arlene Chapman,Peili Chen
Arlene Chapman
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by epithelial proliferation and progressive cyst enlargement. Using a non-targeted high-resolution metabolomics approach, we analyzed biofluids from 36 ADPKD and 18 healt...
DECODING STROKE DISPARITIES: ZIP CODES, COLOR CODES, AND EPIGENETIC CODES [0.03%]
解读卒中的差异性：邮政编码、肤色和表观遗传密码
Bruce Ovbiagele
Bruce Ovbiagele
Despite decreases in overall stroke incidence and mortality in the United States, racial and ethnic disparities continue unabated. Of note, the long-standing disproportionate burden of stroke on African Americans compared to other racial an...
Charles J Lowenstein
Charles J Lowenstein
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. VTE is caused by genetic and acquired conditions, but the genetic variants that increase the risk of VTE are not fully characterized. Recent geno...
THE JEREMIAH METZGER LECTURE: TURNING GENES INTO MEDICINES: HIGHLIGHTS AND HURDLES IN THE DEVELOPMENT OF GENE THERAPY FOR GENETIC DISEASE [0.03%]
遗传疾病的基因治疗开发中的亮点与障碍
Katherine A High
Katherine A High
The journey from in vitro transfer of genes into mammalian cells to approved gene therapy products has spanned decades. This manuscript summarizes hurdles encountered and obstacles overcome in the development of successful adeno-associated ...
CLINICAL HETEROGENEITY IN THE AGE OF BIG DATA, ADVANCED ANALYTICS, AND COMPLEXITY THEORY [0.03%]
大数据、高级分析和复杂性理论时代的临床异质性问题
David Herrington,Yue Wang
David Herrington
Clinical heterogeneity remains a challenge in the practice of medicine and is an underlying motivation for much of biomedical research. Unfortunately, despite an abundance of technologies capable of producing millions of discrete data eleme...