Joshua C Denny
Joshua C Denny
The National Institutes of Health's All of Us Research Program is building one of the most comprehensive research cohorts in the United States. Launched in 2018, the program has enrolled more than 849,000 individuals to empower precision me...
Richard A Lange
Richard A Lange
Anita Deswal
Anita Deswal
Obesity is a risk factor for incident heart failure (HF), linked to, but also independent of, coexisting comorbidities. The association of obesity is stronger for HF with preserved versus reduced ejection fraction. Further, obesity is assoc...
PREVENTION OF HEALTH CARE-ASSOCIATED INFECTIONS IN U.S. HEALTH SYSTEMS: HARNESSING THE GUT MICROBIOME TO COMBAT INFECTION [0.03%]
美国医疗体系中预防与治疗医疗相关感染：利用肠道微生物防治感染
Nasia Safdar
Nasia Safdar
Health care-associated infections (HAIs) remain a major challenge in the U.S. health care system, with Clostridioides difficile (C. difficile or C. diff) being the most prevalent. The use of antibiotics disrupts the gut microbiota, predispo...
CLEAVAGE OF IGFBP-1 BY AN ENZYME IN URINE PREDICTS THE FUTURE NEED FOR KIDNEY REPLACEMENT THERAPY IN ACUTE KIDNEY INJURY [0.03%]
急性肾损伤患者尿液中IGFBP-1降解产物与未来需要肾脏替代治疗的关联性预测研究
John M Arthur,Joseph H Holthoff
John M Arthur
The only Food and Drug Administration (FDA)-approved biomarker for prediction of acute kidney injury (AKI) in adults has a false positive rate (FPR) of 50%. We identified insulin-like growth factor-binding protein 1 (IGFBP-1) as a good but ...
IRON DEFICIENCY PROMOTES HELICOBACTER PYLORI-INDUCED GASTRIC CARCINOGENESIS BY ENABLING RECIPROCITY BETWEEN CARCINOGENIC SECONDARY BILE ACIDS AND PROTECTIVE LONG-CHAIN FATTY ACIDS [0.03%]
铁缺乏通过促进致癌次级胆酸与长链脂肪酸之间的相互作用来促进幽门螺杆菌诱导的胃癌发生发展
Richard M Peek,James D Carmichael,M Blanca Piazuelo et al.
Richard M Peek et al.
Helicobacter pylori (Hp) is the strongest known risk factor for gastric adenocarcinoma. We previously demonstrated that iron deficiency, a condition of the exposome, augments Hp-induced carcinogenesis. To define mechanisms driving this phen...
Patricia L Winokur
Patricia L Winokur
Novel avian influenza viruses continue to circulate in animal species around the world and show a propensity to reassort and acquire virulence factors, which raises the concern that these viruses may adapt to humans. Pandemic preparedness h...
Lynn M Schnapp
Lynn M Schnapp
Pericytes are specialized, mural cells essential to vascular integrity and homeostasis, with emerging roles in lung injury, fibrosis, and viral pathology. Situated around capillaries, pericytes can transition into myofibroblast-like cells a...
REDEFINING AUTOIMMUNE DISEASES: THE OPPORTUNITY FOR PRECISION AND PREVENTION [0.03%]
重新定义自身免疫病：精准医疗与预防的机会
David R Karp
David R Karp
In aggregate, autoimmune diseases affect at least 8% of the U.S. population, making them a significant health problem. Multiple lines of evidence accumulated over the last 20+ years have clearly demonstrated that the pathophysiology leading...