PRIMARY STROKE PREVENTION IN CHILDREN WITH SICKLE CELL ANEMIA LIVING IN AFRICA: THE FALSE CHOICE BETWEEN PATIENT-ORIENTED RESEARCH AND HUMANITARIAN SERVICE-PART II [0.03%]
非洲镰状细胞贫血儿童的一级中风预防：以患者为导向的研究与人道主义服务的取舍（第二部分）
Michael R Debaun
Michael R Debaun
In the United States, primary stroke prevention in children with sickle cell anemia (SCA) is the standard of care and includes annual transcranial Doppler ultrasound to detect elevated velocities. For children with velocities ≥200 cm/sec, ...
Randomized Controlled Trial
Transactions of the American Clinical and Climatological Association. 2022:132:236-248. DOI: 2022
CHANGE LEADERSHIP AND CRISIS MANAGEMENT: CURRICULUM TRANSFORMATION BEFORE, DURING, AND AFTER A PANDEMIC [0.03%]
变革领导力与危机管理：疫情前、期间和之后的课程改革
Eva Aagaard
Eva Aagaard
Washington University School of Medicine has not undergone substantive curricular change for 25 years. In 2018, we embarked on a curriculum transformation project informed by the change leadership principles of James Kotter and William Brid...
Antony Rosen
Antony Rosen
The striking association of specific autoantibodies with distinct disease phenotypes and trajectories in human autoimmune rheumatic diseases provides a powerful opportunity to interrogate disease mechanism. In scleroderma, a subgroup of pat...
THE JEREMIAH METZGER LECTURE:VON HIPPEL-LINDAU DISEASE: INSIGHTS INTO OXYGEN SENSING, CANCER AND DRUGGING THE UNDRUGGABLE [0.03%]
揭秘von Hippel-Lindau疾病：氧感知、癌症与药物开发的启示
William G Kaelin Jr
William G Kaelin Jr
Germline VHL mutations predispose to hemangioblastomas of the retina, cerebellum, and spinal cord; clear cell renal cell carcinomas (ccRCCs); and paragangliomas. Consistent with the Knudson two-hit model, somatic biallelic VHL mutations are...
Gary V Desir
Gary V Desir
While investigating the mechanisms that could mediate the significant burden of cardiovascular complications observed in persons with chronic kidney disease (CKD) and end stage renal disease (ESRD), we identified a previously unknown protei...