Understanding the link between regulatory RNA regions and genomic variation in coeliac disease [0.03%]
理解调节性RNA区域与乳糜泻基因组变异之间的联系
Izei Pascual-González,Izortze Santin,Ainara Castellanos-Rubio
Izei Pascual-González
Coeliac disease (CD) is a chronic immune-mediated inflammatory disorder triggered by dietary gluten ingestion in genetically predisposed individuals. While gluten-specific T cells and HLA-DQ2/DQ8 alleles are critical to the disease onset, t...
Crosstalk between T cell gene regulation and intestinal epithelial cells: Insights into mucosal immunity [0.03%]
T细胞基因调控与肠道上皮细胞之间的串扰：黏膜免疫的新见解
Dora Bordoni,Antonella Fazio
Dora Bordoni
The intestinal epithelium serves as a critical mechanical barrier against potentially pathogenic bacteria and their antigens while maintaining immune homeostasis and facilitating nutrient and water absorption. In the gut, T cells undergo a ...
Disentangling the multi-omics layers of complex traits: Celiac disease as a model [0.03%]
解开复杂性状的多组学层：乳糜泻作为模型疾病
Juliana Xavier de Miranda Cerqueira
Juliana Xavier de Miranda Cerqueira
The post-genomic era has ushered in a transformative shift in biomedical research, driven by the integration of multi-omics technologies and advanced computational tools. While genome-wide association studies (GWAS) have identified thousand...
María Isabel San-Martín,África Sanchiz,Nicolas Navasa
María Isabel San-Martín
Throughout human history, pathogens have exerted great pressure on human genome that have defined susceptibility to both infectious and autoimmune diseases. This is possible because both type of conditions share susceptibility loci. The eme...
Unraveling the interplay of genetic variants and epigenetic signatures in complex traits [0.03%]
解开遗传变异与表观遗传特征在复杂性状中的相互作用
Lana Pacheco Franco-Gedda,Renato Heidor,Maria Aderuza Horst
Lana Pacheco Franco-Gedda
Complex traits, characterized by their reliance on multiple genetic variants and intricate environmental influences, present a unique challenge in the field of genetics. At the core of complex traits lies the interaction between numerous ge...
David Meseguer García
David Meseguer García
Obesity is increasingly recognized not only for its systemic health impacts but also for its association with visual defects and eye diseases. This chapter explores the relationship between obesity and ocular health, highlighting the mechan...
Aditya Shah,Clancy O Bush,Rachel J Perry
Aditya Shah
Genetics is a significant risk factor for developing type 2 diabetes, with a family history conferring a 1.5-3-fold increased risk. Intriguingly, this heritable risk is higher when the affected parent is the mother, suggesting a potential r...
Suhani Hingar,Marc Schneeberger Pané,María José Ortuño Romero
Suhani Hingar
Prader-Willi syndrome (PWS) is a complex genetic disorder arising from abnormalities on chromosome 15q11.2-q13, characterized by distinct physical, cognitive, and behavioral features that evolve across the lifespan. Early manifestations inc...
Parkinson's disease and metabolic disorders, understanding their shared co-morbidity through the autonomic nervous system [0.03%]
帕金森病和代谢障碍，通过自主神经系统了解它们共有的合并症
Thanh N Pham,Rebecca E Schelling,Ken H Loh
Thanh N Pham
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor dysfunctions. Its pathological hallmark is the aggregation of ɑ-synuclein in the central nervous system (CNS), leading to widespread l...