Shaping mammalian genomes: The regulation and co-option of transposable elements in early development and gametogenesis [0.03%]
塑造哺乳动物基因组：转座元件在早期发育和生殖细胞发生中的调控与利用
Antonio Docavo Garcia,Joanna W Jachowicz
Antonio Docavo Garcia
Transposable elements (TEs), or mobile genetic elements, are fragments of DNA capable of moving from one genomic location to another. Traditionally, transposons have been considered selfish genetic elements because they increase their copy ...
Alejandro Fuentes-Iglesias,Raquel García-Vílchez,Diana Guallar
Alejandro Fuentes-Iglesias
This chapter reviews the current understanding of the role of transposable elements (TEs) in the aging process. TEs represent a significant proportion of mammalian genomes and, far from being "junk DNA", they harbor important functions as r...
Transposable elements in human cancer: Regulation, activation, and genomic consequences [0.03%]
人类癌症中的转座元件：调控、激活及基因组影响
Layla Diaz-Portal,Jesús Emiliano Sotelo-Fonseca,Bernardo Rodriguez-Martin
Layla Diaz-Portal
Transposable elements (TEs) are mobile DNA sequences that have played a central role in shaping the human genome. Among them, LINE-1 (L1) elements are particularly relevant in cancer, as most reported somatic activity originates from them. ...
Retrotransposons as both "architects" and "saboteurs" in the nervous system [0.03%]
逆转录转座子在神经系统的进化中扮演着“建筑师”和“破坏者”的双重角色
Nuria Izquierdo-Useros,Mara Dierssen,Bonaventura Clotet et al.
Nuria Izquierdo-Useros et al.
Transposable elements (TEs), once dismissed as genomic "junk," are now recognized as major forces shaping the architecture, function, and evolution of the nervous system. Among them, retrotransposons-particularly Long Interspersed Nuclear E...
Braulio Valdebenito-Maturana
Braulio Valdebenito-Maturana
Transposable Elements (TEs) have the ability to transpose, and have populated all known eukaryotic genomes to date. Nowadays, their role in many aspects of biology, from population diversity to gene regulatory networks is well recognized. O...
Izei Pascual-González,Henar Rojas-Márquez
Izei Pascual-González
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of immune and inflammatory responses. Recent studies have highlighted the involvement of lncRNA in several inflammatory pathways such as NF-κB, MAPK, and JAK/STAT, where ln...
Chemokines and their receptors: The importance of their expression for an appropriate regulation of the immune response in health and disease [0.03%]
趋化因子及其受体：它们的表达对于健康和疾病中适当的免疫反应调节的重要性
Maialen Sebastian-delaCruz
Maialen Sebastian-delaCruz
Leukocytes are typically migratory immune cells, and their migration is of critical immunological importance. In this context, chemokines and their receptors play a dynamic role in regulating the functions of leukocytes within the immune sy...
The JAK-STAT signaling pathway in inflammatory and autoimmune diseases: Its potential role as a therapeutic target [0.03%]
jak-stat信号转导通路在炎症及自身免疫病中的作用及其作为治疗靶点的潜力分析
Leire Bergara-Muguruza,Kaan Gundogdu,Izortze Santin
Leire Bergara-Muguruza
The JAK-STAT signaling pathway is essential for regulating pro-inflammatory and immune responses across various cell types. Its involvement in inflammation has linked it to the pathogenesis of numerous autoimmune and inflammatory diseases. ...
Carolina Chiale
Carolina Chiale
Interferons are key mediators of antiviral defense. They enable infected cells and specialized immune populations to mount rapid transcriptional responses that restrict viral replication and support immune activation. Type I and type III in...
Ruxiao Yang-Fischer,Alyssa Shearer,Sankar Ghosh
Ruxiao Yang-Fischer
Autoimmune diseases represent a complex class of disorders characterized by the immune system's aberrant attack on self-tissues, driven by intricate genetic and environmental factors. Long noncoding RNAs (lncRNAs), a diverse class of transc...