Izei Pascual-González,Henar Rojas-Márquez
Izei Pascual-González
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of immune and inflammatory responses. Recent studies have highlighted the involvement of lncRNA in several inflammatory pathways such as NF-κB, MAPK, and JAK/STAT, where ln...
Chemokines and their receptors: The importance of their expression for an appropriate regulation of the immune response in health and disease [0.03%]
趋化因子及其受体：它们的表达对于健康和疾病中适当的免疫反应调节的重要性
Maialen Sebastian-delaCruz
Maialen Sebastian-delaCruz
Leukocytes are typically migratory immune cells, and their migration is of critical immunological importance. In this context, chemokines and their receptors play a dynamic role in regulating the functions of leukocytes within the immune sy...
The JAK-STAT signaling pathway in inflammatory and autoimmune diseases: Its potential role as a therapeutic target [0.03%]
jak-stat信号转导通路在炎症及自身免疫病中的作用及其作为治疗靶点的潜力分析
Leire Bergara-Muguruza,Kaan Gundogdu,Izortze Santin
Leire Bergara-Muguruza
The JAK-STAT signaling pathway is essential for regulating pro-inflammatory and immune responses across various cell types. Its involvement in inflammation has linked it to the pathogenesis of numerous autoimmune and inflammatory diseases. ...
Carolina Chiale
Carolina Chiale
Interferons are key mediators of antiviral defense. They enable infected cells and specialized immune populations to mount rapid transcriptional responses that restrict viral replication and support immune activation. Type I and type III in...
Ruxiao Yang-Fischer,Alyssa Shearer,Sankar Ghosh
Ruxiao Yang-Fischer
Autoimmune diseases represent a complex class of disorders characterized by the immune system's aberrant attack on self-tissues, driven by intricate genetic and environmental factors. Long noncoding RNAs (lncRNAs), a diverse class of transc...
Rodrigo Sánchez-Tarjuelo
Rodrigo Sánchez-Tarjuelo
Recent discoveries in the field of epigenetic regulation have shed light on the intricate processes of immune cell activation, differentiation, and function in response to threats. Epigenetics connects genetic and environmental factors and ...
Understanding the link between regulatory RNA regions and genomic variation in coeliac disease [0.03%]
理解调节性RNA区域与乳糜泻基因组变异之间的联系
Izei Pascual-González,Izortze Santin,Ainara Castellanos-Rubio
Izei Pascual-González
Coeliac disease (CD) is a chronic immune-mediated inflammatory disorder triggered by dietary gluten ingestion in genetically predisposed individuals. While gluten-specific T cells and HLA-DQ2/DQ8 alleles are critical to the disease onset, t...
Crosstalk between T cell gene regulation and intestinal epithelial cells: Insights into mucosal immunity [0.03%]
T细胞基因调控与肠道上皮细胞之间的串扰：黏膜免疫的新见解
Dora Bordoni,Antonella Fazio
Dora Bordoni
The intestinal epithelium serves as a critical mechanical barrier against potentially pathogenic bacteria and their antigens while maintaining immune homeostasis and facilitating nutrient and water absorption. In the gut, T cells undergo a ...
Disentangling the multi-omics layers of complex traits: Celiac disease as a model [0.03%]
解开复杂性状的多组学层：乳糜泻作为模型疾病
Juliana Xavier de Miranda Cerqueira
Juliana Xavier de Miranda Cerqueira
The post-genomic era has ushered in a transformative shift in biomedical research, driven by the integration of multi-omics technologies and advanced computational tools. While genome-wide association studies (GWAS) have identified thousand...