Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms [0.03%]
组蛋白序列变异体和翻译后修饰形式的蛋白质组分析
Palina Ryzhaya,Pavlína Pírek,Radomír Pech et al.
Palina Ryzhaya et al.
Post-translational modifications (PTMs) of histone variants are the key mechanisms driving epigenetic regulation. They play a crucial role in modulating chromatin structure and gene activity. As epigenetics has become a foundational aspect ...
Advanced (Nano)material-Based Enrichment Strategies for Quantitative Phosphoproteomics Analysis by Mass Spectrometry [0.03%]
基于高级(纳米)材料的 enrichment策略用于定量磷酸蛋白质组学质谱分析
Inmaculada Ortiz-Gómez,Francisco Calderón Celis
Inmaculada Ortiz-Gómez
Phosphorylation is one of the most prevalent and dynamic post-translational modifications. It regulates aspects of cellular signaling, metabolism, and disease progression. Comprehensive characterization of phosphoproteins and their phosphor...
Metaproteomics for Water Biotechnology: Considerations and Study Cases [0.03%]
水技术领域的元蛋白质组学：注意事项及案例研究
Ana C Afonso,Juan M Lema,Alba Trueba-Santiso
Ana C Afonso
This chapter summarizes the current knowledge on the practical, methodological, and interpretative aspects of applying metaproteomics in water biotechnology. We outline the full metaproteomic workflow-from sampling and protein extraction to...
LC-MS-Based Metabolomics and Proteomics Sample Preparation of Urine: Methods and Multi-Omics Integration [0.03%]
基于LC-MS的尿液代谢组学和蛋白质组学样品制备：方法及多组学整合
Muath Khairi Mousa,Nelson C Soares,Hugo M Santos
Muath Khairi Mousa
Urine is an ideal biological fluid due to the highly metabolomic and proteomic information it provides and its easy collection in large amounts. Urinary biomarkers reported for different types of diseases included the urological tract and s...
Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases [0.03%]
哺乳动物呼吸链复合物的组装及其与线粒体应激诱导的人类疾病的关系
Runyu Guo,Maojun Yang
Runyu Guo
Mitochondria are considered the central organelle in cellular energy metabolism and an integral platform for signal transduction. Respiratory chain complexes are the most abundant and critical protein machines in mitochondria. Thanks to adv...
Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications [0.03%]
核苷酸代谢中的酶复合体：结构、调控及其疾病意义
Jack P Boylan,Timothy D Iles,Alexis Nguyen et al.
Jack P Boylan et al.
Nucleotide biosynthesis is essential for cell growth and relies on the coordination of both salvage and de novo pathways to satisfy intracellular needs. While traditionally, the regulation of these pathways has been attributed to factors li...
The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology [0.03%]
丙酮酸脱氢酶复合物：一个90年的谜团塑造结构酶学的未来
Toni K Träger,Fotis L Kyrilis,Greg Kafetzopoulos et al.
Toni K Träger et al.
The ancient pyruvate dehydrogenase complex (PDHc) performs the "link reaction" of cellular respiration-a discovery from the 1930s that was central in the award of the 1953 Nobel Prize in Physiology and Medicine to Krebs and Lipmann. Fast fo...
Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation [0.03%]
Lon介导的λN降解对反终止子RNA转录复合物的调节作用
Marianita Castro,Sanghyuk Lee,Irene Lee
Marianita Castro
The lambda N protein (λN) is an intrinsically unstructured protein functioning to mediate anti-termination transcription of lambda phage RNA during the infection of Escherichia coli (E. coli) host by interacting with the host's macromolecu...
PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus [0.03%]
PCNA巨分子复合物：PCNA作为分子中心调节细胞内和细胞核内外多种生命过程
Hamsini Kala,Dana Abou Abbas,Linda H Malkas et al.
Hamsini Kala et al.
With over 27,100 papers currently written about Proliferating Cell Nuclear Antigen (PCNA) and more than 11,700 papers describing a role for the protein and its relationship to cancer, this chapter will just touch upon some of the important ...
Paras Gaur,Maria Spies
Paras Gaur
The integrity of the human genome is continuously challenged by diverse endogenous and exogenous threats that damage DNA and disrupt its replication. When the replication machinery encounters such obstacles, including lesions or non-canonic...