Julie Y Ji
Julie Y Ji
The ability of vascular endothelium to sense and respond to the mechanical stimuli generated by blood flow is pivotal in maintaining arterial homeostasis. A steady laminar flow tends to provide atheroprotective effect via regulating endothe...
Qing-Ping Yao,Zhong-Qian Liu,Meng-Xiao Li et al.
Qing-Ping Yao et al.
The vascular wall is continuously exposed to complex hemodynamic forces in vivo due to blood flow. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) experience distinct mechanical stresses, primarily shear stress and cyclic s...
Lorna K Milne,Kenton P Arkill
Lorna K Milne
Glycosaminoglycans (GAGs) are polysaccharide chains that extend into the vascular lumen and are embedded throughout the capillary wall. They have a multitude of biophysical and biochemical roles including control of vascular permeability, s...
The Molecular Structure of the Endothelial Glycocalyx. Models to Interpret High-Resolution Imaging of an Ordered Structure for the Molecular Filter at the Microvascular Wall [0.03%]
血管内皮糖萼的分子结构及其有序过滤屏障的高分辨率成像模型
Fitz-Roy E Curry
Fitz-Roy E Curry
The endothelial glycocalyx is a complex fibrous network of molecules that extends from the endothelial cell membrane for distances that range from less than 0.3 micron to several microns. The mechanisms determining the overall organization ...
Ye Zeng,Bingmei M Fu,John M Tarbell
Ye Zeng
Endothelial cells (ECs), which form the inner lining of the vasculature, are perpetually exposed to mechanical stimuli from blood flow. Their capacity to sense and respond to these forces is essential for vascular homeostasis. A diverse arr...
Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights [0.03%]
肽组学研究亮点：先进的样品处理技术与分析见解
Alessio Lenzi,Mariano De Cristofaro,Denise Biagini et al.
Alessio Lenzi et al.
In recent years, the analysis of intact peptides (peptidomics) has remained a relatively under-explored field, where its potential as a bridge between proteomics and metabolomics has only recently been recognized. Currently, immunoassay tec...
Ilaria Iacobucci,Flora Cozzolino,Irene Cipollone et al.
Ilaria Iacobucci et al.
Biomolecular interactions involving proteins, nucleic acids, and small molecules constitute the molecular foundation of cellular regulation, signaling, and therapeutic intervention. Advances in mass spectrometry-based proteomics have enable...
Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches [0.03%]
微生物细胞表面蛋白质组学样品制备策略：剃须法和无载体蛋白组学方法的整合
Dorota Satala,Katarzyna Kowalik,Justyna Karkowska-Kuleta
Dorota Satala
A range of mass spectrometry-based proteomic approaches is now employed to characterize the surface proteome-surfaceome-of pathogenic microorganisms, including fungi capable of causing infections in humans. Nevertheless, the preparation of ...
Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study [0.03%]
石油工业中的蛋白质组样品制备：生物腐蚀案例研究
Icoquih Zapata-Peñasco,Jorge Herrera-Díaz
Icoquih Zapata-Peñasco
Petroleum-associated environments are among the most chemically complex and biologically extreme systems encountered in the field of industrial biotechnology. Here, microbial activity plays a pivotal role in hydrocarbon biodegradation, rese...
Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells [0.03%]
野生型和Lyn缺陷基质细胞的外泌体蛋白质组学及功能比较
Thaís Dolzany de Oliveira,Prerana Wagle,Hinrich P Hansen
Thaís Dolzany de Oliveira
Chronic lymphocytic leukemia (CLL) progression critically depends on bidirectional communication between malignant B cells and non-malignant bystander cells within the tumor microenvironment, including stromal cells, macrophages, and T lymp...