Metabolic Reprogramming in the Bladder Cancer Microenvironment: Bridging Fundamental Research and Therapeutic Avenues for Cancer-Associated Fibroblasts [0.03%]
代谢重塑与膀胱癌微环境：面向癌症相关成纤维细胞的基础研究和治疗途径之间的桥梁
Ana Silva,Fátima Baltazar,Julieta Afonso
Ana Silva
Bladder cancer (BC) is one of the most common malignancies of the urinary tract, characterized by high recurrence rates and, in advanced stages, resistance to therapy and poor prognosis. Cancer and stromal cells of the BC microenvironment o...
Gut-Liver Microbiome and Tumor Microenvironment in Metabolic Dysfunction-Associated Steatotic Liver Disease [0.03%]
代谢功能障碍相关性肝脂肪变性疾病中肠道-肝脏微生态与肿瘤微环境的关系研究
Jeremy Chimene-Weiss,Brittany Bromfield,Theodore Feldman et al.
Jeremy Chimene-Weiss et al.
Hepatocellular carcinoma (HCC), the dominant form of primary liver cancer associated with cirrhosis, has been increasing in prevalence in the US and globally. Metabolic dysfunction-associated steatotic liver disease (MASLD), which is linked...
Metabolism-Driven Modulation by the Human Microbiota: Implications for Cancer Therapy and Emerging Strategies [0.03%]
人体微生物群的代谢调控：对癌症治疗和新兴策略的意义
Laura Gouveia,Jacinta Serpa,Cindy Mendes
Laura Gouveia
The human microbiome plays a pivotal role in cancer development, progression, and therapeutic response. Epidemiologic studies have established links between microbiome composition and various malignancies, with specific microbial taxa exert...
Glucose and Lactate, Starters or Intermediates of Cancer Metabolic Rewiring [0.03%]
葡萄糖和乳酸是癌症代谢重组的始作俑者还是中间产物？
Cindy Mendes
Cindy Mendes
Cancer cells undergo extensive metabolic reprogramming to sustain rapid proliferation and adapt to the hostile conditions of the tumor microenvironment. Central to this metabolic shift are glucose and lactate, which serve not only as essent...
The Interdependence of Carbon Substrates and Metabolic Pathways Enables the Metabolic Plasticity of Cancer Cells [0.03%]
癌细胞碳底物和代谢途径的相互依存性使其具有代谢可塑性
Inês Serpa-Gonçalves,Jacinta Serpa
Inês Serpa-Gonçalves
The tumor microenvironment (TME) functions as a dynamic and co-evolving ecosystem, where malignant and non-malignant cells form a metabolically interdependent community. This ecological view reimagines tumors not as isolated cell masses, bu...
The Convergence of Ancient Medical Wisdom and Modern Physiology: Sodium Ion Wave Propagation in Endothelial Cells, IL-1 Vascular Pathways, and the Six-Day Progression Pattern of Clinical Symptoms [0.03%]
古典医学智慧与现代生理学汇聚——钠离子波在内皮细胞中的传导，IL-1血管通路，以及临床症状六日演变规律
Yang Liu
Yang Liu
The Yellow Emperor's Inner Canon (YEIC) stands as China's most significant ancient medical text, categorizing the human vascular system as a meridian network divided into six major functional categories. The discovery of mapping between Tra...
3D Computational Modeling of Blast Wave Transmission from External Ear to Cochlear Hair Cells [0.03%]
从外耳到耳蜗毛细胞的冲击波三维计算模型仿真研究
Yijie Jiang,Rong Z Gan
Yijie Jiang
The human ear is a complex biomechanical system that transduces sound or blast waves into cochlear hair cells for sensory perception. Understanding the full pathway of mechanical energy transmission, from the external ear through the middle...
Therapeutic Hypothermia for Neurological Injuries: Balancing Neuroprotection with Risks [0.03%]
神经系统损伤的治疗性低温疗法：权衡神经保护与风险益处关系
Liang Zhu
Liang Zhu
While the therapeutic potential of hypothermia for treating tissue damage has been investigated for over 90 years, its effectiveness is still debated. This review introduces the history of hypothermia in medicine first, followed by a descri...
Mathematical Descriptions of Damage to Cells and Tissues Following Heating [0.03%]
关于加热导致的细胞和组织损伤的数学描述公式
Neil T Wright
Neil T Wright
The cells of the cardiovascular system can experience temperature excesses of a few degrees during a diseased state or of tens of degrees during a thermal therapy treatment. These raised temperatures may be acute or of long duration. The mu...
Sanam Pudasaini,Xinghui Wu,Chun Yang
Sanam Pudasaini
Electroporation is a biophysical phenomenon in which cell membranes are transiently permeabilized under an applied electric field, and it can be used for the intracellular delivery of a wide range of molecules, including nucleic acids, prot...