Cysteine Metabolism in the Control of Oxidative Stress in Cancer, Focusing on Carbon and Sulfur Metabolism [0.03%]
半胱氨酸代谢在癌症氧化应激调控中的作用及其碳和硫代谢机制
Susana Parreiras,Jacinta Serpa
Susana Parreiras
Cysteine is a critical metabolic hub in cancer cells, essential for survival and progression, as it serves as a precursor to glutathione, a key antioxidant that mitigates oxidative stress and contributes to chemoresistance. Beyond antioxida...
Catarina Freitas-Dias,Cindy Mendes
Catarina Freitas-Dias
Lung cancer remains the leading cause of cancer-related deaths worldwide in both men and women. Although conventional chemotherapy has been the backbone of treatment, it often fails to provide long-term survival benefits for most patients. ...
Bruno António Cardoso
Bruno António Cardoso
Epigenetic deregulation is a hallmark of myeloid malignancies, shaping their initiation, progression, and therapeutic response. Unlike genetic alterations, epigenetic modifications, such as DNA methylation, histone acetylation, and chromati...
Bruno António Cardoso
Bruno António Cardoso
Epigenetic alterations have emerged as central contributors to the pathogenesis, progression, and therapeutic response in cancer, and in this particular case, which we are discussing, myeloid malignancies. Unlike genetic mutations, epigenet...
Influence of RNA Modifications on Cancer Metabolism: Interplay with Hypoxia and Therapeutic Implications [0.03%]
RNA修饰对癌症代谢的影响：与缺氧的相互作用及治疗意义
Catarina Guimarães-Teixeira,Vera Miranda-Gonçalves,Rui Henrique et al.
Catarina Guimarães-Teixeira et al.
Metabolic reprogramming is a well-established hallmark of cancer, with tumors often altering glucose and lipid metabolism to fuel their rapid growth and survival. Hypoxia, a common feature of the tumor microenvironment, exacerbates these me...
Cell-Free DNA (cfDNA), Its Applications in Cancer Diagnosis and Monitoring, and Its Potential Role in Regulating Cancer Metabolism [0.03%]
细胞游离DNA（cfDNA）在癌症诊断和监测中的应用及其可能的肿瘤代谢调节作用
Catarina Freitas-Dias,Isabel Lemos,Stefano Mazzoleni et al.
Catarina Freitas-Dias et al.
Cell-free DNA (cfDNA) has emerged as a valuable biomarker in cancer diagnosis, monitoring, and prognosis. cfDNA refers to small fragments of DNA that are released into the bloodstream from tumor cells, normal cells, or dying cells within th...
Epigenetics and One-Carbon Metabolism in Cancer: Mechanisms and Therapeutic Implications [0.03%]
表观遗传及一碳代谢在癌症中的作用：机制和治疗意义
Jacinta Serpa,Joana R Costa
Jacinta Serpa
Epigenetics refers to heritable changes in gene expression that occur without alterations in the DNA sequence itself, primarily through mechanisms such as DNA methylation and histone modifications. These regulatory processes are essential f...
Dissecting Cancer Metabolism and Therapeutic Resistance Using In Vitro Platforms [0.03%]
利用体外平台解析癌症代谢和治疗抗性
Bruna Abreu,Isabel Lemos,Jacinta Serpa
Bruna Abreu
Understanding cancer metabolism and its adaptations is critical for developing novel therapeutic strategies. In vitro models remain indispensable tools for dissecting tumor biology and testing metabolism-based therapies. Traditional 2D mono...
Immunity and Beyond: Emerging Roles of Monocytes and Macrophages in Cancer [0.03%]
免疫系统与癌症：单核细胞和巨噬细胞的新兴作用关系研究
Ana Tomás,Marta Pojo
Ana Tomás
Monocytes and macrophages are key regulators of cancer progression, exhibiting remarkable plasticity. Classically involved in initiating pro-inflammatory responses against tumors, these cells can be co-opted by the tumor microenvironment to...
Metabolic Symbiosis Between Cancer Cells and Endothelial Cells: A Key Driver of Tumor Angiogenesis [0.03%]
癌细胞与内皮细胞之间的代谢共生：肿瘤血管生成的关键驱动因素
Jacinta Serpa
Jacinta Serpa
This chapter explores the critical role of angiogenesis in cancer, focusing on the metabolic processes involved in angiogenesis, particularly the metabolic remodeling of endothelial cells (ECs) and the symbiosis between cancer cells and ECs...