Recent Progress in Characterizing Germline Mutations and Their Transmission Across Generations [0.03%]
近期的生殖系突变及其跨代传递的研究进展
Ami Katanaya,Tomoatsu Takano,Mihoko Hosokawa et al.
Ami Katanaya et al.
Genome mutations in germ cells are fundamental to evolution and genetic diversity, while they also cause developmental abnormalities and genetic diseases, making their study essential in both biology and medicine. Research on germline mutat...
Peilin Li,Tatsuya Ohhata,Satoshi Sakai et al.
Peilin Li et al.
Male germline development is characterized by a unique perinatal phase in which primordial germ cells (PGCs) differentiate into gonocytes (prospermatogonia) and subsequently give rise to spermatogonia. This chapter outlines the cellular, mo...
Mathematical Modeling in Cancer Metabolism: Tools for Translational Applications in Metabolism-Based Therapy [0.03%]
数学模型与癌症代谢：基于代谢的治疗转化型应用工具
José Alberto Rodrigues,João Serra Lopes
José Alberto Rodrigues
Cancer metabolism is characterized by extensive reprogramming of biochemical pathways, enabling malignant cells to sustain proliferation, adapt to fluctuating environments, and resist therapeutic stress. While the Warburg effect has long be...
Lipid Remodeling and Metabolic Adaptation in Cancer Cell Membranes: A Platform for Membrane-Targeted Nanotherapy [0.03%]
癌细胞膜的脂质重构和代谢适应：面向膜靶向纳米治疗的平台
Adriana Cruz,Vasco D B Bonifácio
Adriana Cruz
Metabolic reprogramming in cancer cells induces profound alterations in membrane lipid organization, affecting phospholipid distribution, surface charge, and overall lipid composition. These modifications contribute to key oncogenic process...
Bruna F Correia,Daniela Grosa,M Guadalupe Cabral
Bruna F Correia
Immune metabolism is a central determinant of neutrophil development, plasticity, and function. Once considered strictly glycolytic, neutrophils are now recognized as metabolically flexible cells that dynamically engage glycolysis, the pent...
Cysteine Metabolism as a Central Metabolic Driver and Selenocompounds as Therapeutic Agents [0.03%]
半胱氨酸代谢作为中心代谢驱动因素和硒化合物作为治疗剂
Bruna Abreu,Jacinta Serpa
Bruna Abreu
Amino acid metabolism plays a vital role in both health and disease, supporting essential processes such as protein synthesis, signaling, energy production, and epigenetic regulation. Among the amino acids, cysteine is particularly notable ...
João S Patrício,Ana C L Guerreiro,Paulo A Gameiro et al.
João S Patrício et al.
Mass spectrometry (MS) is a highly sensitive and high-throughput analytical technology that has become central to investigating the metabolic alterations in cancer cells, enabling the discovery of diagnostic biomarkers and potential therape...
Catarina Freitas-Dias,Luís Gafeira Gonçalves
Catarina Freitas-Dias
Nuclear magnetic resonance (NMR) spectroscopy has emerged as an important tool in cancer metabolism research, providing noninvasive, quantitative, and revealing insights into tumor biochemistry. This chapter discusses a wide range of NMR ap...
Mitochondrial Energy Metabolism in Cancer, Immunoregulation and Antitumour Response [0.03%]
线粒体生物能量代谢与癌症、免疫调控及抗肿瘤反应的关系研究进展
João S Patrício,Cindy Mendes,Paulo A Gameiro
João S Patrício
Mitochondria are the cells' powerhouse, a dogma that has guided research for decades. While this bioenergetic view is accurate, it fails to capture the extra-metabolic signalling functions of mitochondria, as well as the complexity of mitoc...
Giovanna Carrà,Alfonso Scalera,Isaia Barbieri et al.
Giovanna Carrà et al.
Ferroptosis is a metabolically regulated, iron-dependent form of cell death driven by lipid peroxidation. This chapter dissects the core metabolic circuits that converge to determine ferroptotic susceptibility and explores the interplay bet...