Modeling with Petri Nets [0.03%]
用Petri网建模
Rza Bashirov
Rza Bashirov
Biochemical networks can be modeled either quantitatively-when kinetic data are available-or qualitatively, based on network topology and stoichiometry. This chapter outlines the fundamental stages involved in the development of quantitativ...
Petri Nets [0.03%]
皮特里网
Rza Bashirov
Rza Bashirov
This chapter reviews the classical PNs and PNs with extensions that will be used in the rest of this book. The key concepts of PNs are demonstrated through running examples in a biochemical context, such as methane combustion, the central d...
Mathematical Modeling of Cell-Cell Fusion Assays to Characterize Virus-Mediated Cell Fusion [0.03%]
数学建模细胞融合测定以表征病毒介导的细胞融合
Hana M Dobrovolny
Hana M Dobrovolny
Syncytia are multinucleated cells created by fusion of normal cells. Some viruses are known to induce syncytia formation as a consequence of infected cells expressing viral surface proteins. The role of syncytia in the spread of viral infec...
Nano- and Microtubes: Tiny Fusion Events but Not Overall Plasma Membrane Merger for Exchanging Intracellular Components [0.03%]
纳米管和微管：不是整体质膜融合但会发生小型融合事件以交换细胞内成分
Xianghe Qiao,Bo Li
Xianghe Qiao
Membrane nanotubes, including tunneling nanotubes (TNTs), tumor microtubes (TMs), cytonemes, and related structures, constitute open-ended conduits that directly connect cells. They enable the directed exchange of organelles, nucleic acids,...
Investigating the Consequences of Aneuploidy in Cancer and Normal Tissue [0.03%]
染色体非整倍性在癌症和正常组织的后果研究
Joanna N Modi,Alison M Taylor
Joanna N Modi
Aneuploidy is an unbalanced number of chromosomes arising from errors during cell division. Under normal conditions, cells use highly precise mechanisms to accurately segregate chromosomes during mitosis and meiosis. Errors in this process ...
Kathryn L Fowler,Ashley N Anderson,Taelor J Ekstrom et al.
Kathryn L Fowler et al.
The interplay between discrete neoplastic cells and cells within the tumor microenvironment represents a critical component of cancer evolution that ultimately impacts patient outcomes. A newly identified neoplastic cell that is a product o...
Cell-Cell Fusion as a Mechanism of Immune Evasion and Metastatic Progression [0.03%]
细胞融合作为免疫逃逸和转移进展的机制
Eduardo López-Collazo,Laura Hurtado-Navarro,Gloria C Bonel-Pérez
Eduardo López-Collazo
The cancer cell fusion theory has emerged in the last few years as a critical yet under-recognised mechanism contributing to tumour progression and metastasis. This chapter revisits its historical foundations and explores the cellular and m...
Genomic Reshuffling After Cell Fusion: Catalyst for Cancer Evolution and Progression [0.03%]
细胞融合后的基因组重排：癌症进化和进展的催化剂
Julian Weiler,Thomas Dittmar
Julian Weiler
The fundamental relevance of cell-cell fusion processes is well studied and involves the precise spatiotemporal coordination of fusion-competent cells and the orchestration of typical fusion stages, ultimately leading to the genesis of a fu...
Cell Fusion-Mediated Induction of Polyploidy, Aneuploidy, and Genomic Instability in Cancer Cells [0.03%]
细胞融合介导的癌细胞多倍体、非整倍体和基因组不稳定性的诱导作用
Tomonori Matsumoto
Tomonori Matsumoto
Cell fusion, which occurs in both tissue injury and cancer, inevitably results in polyploidization. While polyploid cells often fail to proliferate, polyploidization does not invariably lead to growth arrest, and polyploid cells can resume ...
Soham Bhattacharyya,Debopriya Choudhury,Brahmachari Vedeshachaitanya et al.
Soham Bhattacharyya et al.
This chapter explores both the normal physiological roles of cell fusion and its pathological implications in cancer. We focus on the emerging concept of fusion-induced polyploidy and senescence as a "double-edged sword"-a process that can ...