Molecular mechanism of VDE-initiated intein homing in yeast nuclear genome [0.03%]
芽殖酵母核基因组中VDE介导的intein入侵分子机制
Tomoyuki Fukuda,Yuri Nagai,Yoshikazu Ohya
Tomoyuki Fukuda
In Saccharomyces cerevisiae, VMA1 intein encodes a homing endonuclease termed VDE which is produced by an autocatalytic protein splicing reaction. VDE introduces a DSB at its recognition sequence on intein-minus allele, resulting in the lat...
Review
Advances in biophysics. 2004:38:215-32. DOI: 2004
Atsuko Gyohda,Nobuhisa Furuya,Akiko Ishiwa et al.
Atsuko Gyohda et al.
Conservative site-specific recombination plays key roles in creating biological diversity in prokaryotes. Most site-specific inversion systems consist of two recombination sites and a recombinase gene. In contrast, the shufflon multiple inv...
Review
Advances in biophysics. 2004:38:183-213. DOI: 2004
Transposition mechanisms and biotechnology applications of the medaka fish Tol2 transposable element [0.03%]
斑马鱼Tol2转座子的转座机制及生物技术应用
Akihiko Koga
Akihiko Koga
The Tol2 element of the medaka fish is a member of the hAT (hobo/Activator/ Tam3) transposable element family. About 20 copies are present in the medaka fish genome and, unlike many other hAT family elements, virtually all the copies are au...
Review
Advances in biophysics. 2004:38:161-80. DOI: 2004
Genetics and epigenetics in flower pigmentation associated with transposable elements in morning glories [0.03%]
与转座元件相关的牵牛花花瓣色素的遗传和表观遗传
Shigeru Iida,Yasumasa Morita,Jeong-Doo Choi et al.
Shigeru Iida et al.
Among the genus Ipomoea, three morning glories, I. nil (the Japanese morning glory), I. purpurea (the common morning glory), and I. tricolor, were domesticated well for floricultural plants, and many spontaneous mutants displaying various f...
Review
Advances in biophysics. 2004:38:141-59. DOI: 2004
Intermediate molecules generated by transposase in the pathways of transposition of bacterial insertion element IS3 [0.03%]
细菌IS3插入序列转位途径中由转座酶生成的中间分子
Eiichi Ohtsubo,Hiroshi Minematsu,Ken Tsuchida et al.
Eiichi Ohtsubo et al.
Review
Advances in biophysics. 2004:38:125-39. DOI: 2004
Gpt delta transgenic mouse: a novel approach for molecular dissection of deletion mutations in vivo [0.03%]
GptΔ转基因小鼠:体内缺失突变分子分析的新方法
Takehiko Nohmi,Ken-Ichi Masumura
Takehiko Nohmi
Human genome is continuously exposed to various DNA damaging agents including reactive oxygen species. Of various forms of DNA damage, double-strand breaks (DSBs) in DNA are the most detrimental because of the mutagenicity and cytotoxicity....
Review
Advances in biophysics. 2004:38:97-121. DOI: 2004
Cell death promoted by homologous DNA interaction from bacteria to humans [0.03%]
从细菌到人类由同源DNA互作促进的细胞死亡
Kohji Kusano
Kohji Kusano
Pairing between homologous DNA controls cellular functions including double-strand break repair, mitotic recombination, and progression of DNA replication forks, as well as chiasma formation during meiosis. Here I summarize that homologous ...
Review
Advances in biophysics. 2004:38:81-96. DOI: 2004
Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex [0.03%]
Nijmegen断裂综合症与NBS1复合物介导的DNA双链断裂修复
Shinya Matsuura,Junya Kobayashi,Hiroshi Tauchi et al.
Shinya Matsuura et al.
The isolation of the NBS1 gene revealed the molecular mechanisms of DSB repair. In response to DNA damage, histone H2AX in the vicinity of DSBs is phosphorylated by ATM. NBS1 then targets the MRE11/RAD50 complex to the sites of DSBs through...
Review
Advances in biophysics. 2004:38:65-80. DOI: 2004
The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining [0.03%]
解旋酶基因家族(特别是BLM)在DNA重组和连接中的作用
Hideo Kaneko,Toshiyuki Fukao,Naomi Kondo
Hideo Kaneko
Bloom syndrome is a rare autosomal recessive genetic disorder characterized by lupus-like erythematous telangiectasias of the face, sun sensitivity, stunted growth, and immunodeficiency. Chromosome instability syndromes have a common featur...
Review
Advances in biophysics. 2004:38:45-64. DOI: 2004
Genetic and physiological regulation of non-homologous end-joining in mammalian cells [0.03%]
哺乳动物细胞中非同源末端连接的遗传及生理调节机制研究
Akira Tachibana
Akira Tachibana
Repair of DSBs is important to prevent chromosomal fragmentation, translocations and deletions. To investigate the process in NHEJ, we have established an in vitro system to clarify the measurement and analysis of the efficiency and the fid...
Review
Advances in biophysics. 2004:38:21-44. DOI: 2004