Using (+)-Carvone to access novel derivatives of (+)- ent-Cannabidiol: the first asymmetric syntheses of (+)- ent-CBDP and (+)- ent-CBDV [0.03%]
使用(+)-芹菜香柑油烃获得(+)- 内型-大麻二酚的新衍生物：首次不对称合成(+)- 内型-CBDP 和(+)- 内型-CBDV
Alexandra E Golliher,Antonio J Tenorio,Nina O Dimauro et al.
Alexandra E Golliher et al.
(-)-Cannabidiol [(-)-CBD] has recently gained prominence as a treatment for neuro-inflammation and other neurodegenerative disorders; interest is also developing in its synthetic enantiomer, (+)-CBD, which has a higher affinity to CB1 / CB2...
Michael R Stentzel,Douglas A Klumpp
Michael R Stentzel
Dicationic fluorenyl cations are shown to react with nitriles to provide amide-functionalized fluorenes. A similar reaction with alcohols gives ether derivatives. The chemistry is initiated by the reactions of N-heterocyclic ketones in a su...
Convergent Synthesis of (R)-Silodosin via Decarboxylative Cross-Coupling [0.03%]
天冬氨酸衍生物的去羧基交叉偶联及(R)-西洛多辛的汇聚合成
Tie-Gen Chen,Lucas Mele,Olivier Jentzer et al.
Tie-Gen Chen et al.
A new approach to Silodosin capitalizing on a radical retrosynthetic strategy to dissect the molecule into two halves is reported. Using a reductive decarboxylative cross-coupling, a simple indoline can be coupled to a chiral pool-derived f...
Coumarins, dihydroisocoumarins, a dibenzo- α-pyrone, a meroterpenoid, and a merodrimane from Talaromyces amestolkiae [0.03%]
来源于Talaromyces amestolkiae的香豆素、二氢异香豆素、二苯并-α-吡酮、倍半萜杂木脂素及杂螺甾内酯类化合物
Tamam El-Elimat,Mario Figueroa,Huzefa A Raja et al.
Tamam El-Elimat et al.
Chemical investigation of an organic extract of a fungus isolated from submerged wood collected from fresh water (strain G173), identified as a Talaromyces amestolkiae (Eurotiales; Trichocomaceae), led to the isolation of three coumarins, t...
Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant [0.03%]
与JAK2假激酶结构域及其V617F变异体结合的吲哚噁二嗪三氮唑化合物
Ana S Newton,Maria-Elena Liosi,Sean P Henry et al.
Ana S Newton et al.
Small molecules that selectively bind to the pseudokinase JH2 domain over the JH1 kinase domain of JAK2 kinase are sought. Virtual screening led to the purchase of 17 compounds among which 9 were found to bind to V617F JAK2 JH2 with affinit...
Synthesis of C-linked α-Gal and α-GalNAc-1'-hydroxyalkanes by way of C2 functionality transfer [0.03%]
通过C2功能团转移合成C连接的α-半乳糖和α-半乳糖胺-1'-羟基烷烃
Ernest G Nolen,Ezra S Hornik,Kendra B Jeans et al.
Ernest G Nolen et al.
Inspired by reports of water sculpted Tn antigen (α-GalNAc-O-Ser/Thr) epitopes and our interest in producing metabolically more stable C-linked analogs of Tn, we explored the utility of C2 functionality on α-Gal-C-alkenes to deliver hydro...
Formation of Pyrroloindolines via the Alkylation of Tryptamines with Trichloroacetimidates [0.03%]
三氯乙酰亚胺酯与色氨衍生物的烷基化反应合成吡咯并吲哚类化合物
Bhaskar D Joshi,John D Chisholm
Bhaskar D Joshi
Pyrroloindolines and related systems are present in a large number of complex natural products. These core structures have generated considerable synthetic interest, as many of the compounds possess challenging, elaborate structures and int...
Lisa E Rusali,Michael P Schramm
Lisa E Rusali
With an inwardly directed reactive center and a well-defined binding pocket, Au(I) functionalized resorcin[4]arene cavitands have been shown to catalyze molecular transformations. The reactivity profiles that emerge differ from other Au(I) ...
Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates [0.03%]
preferential轻链标记天然单克隆抗体可改善荧光素缀合物的性质
Michael P Luciano,Ivan Dingle,Saghar Nourian et al.
Michael P Luciano et al.
Site specific labeling methods have significant potential to enhance the properties of antibody conjugates. While studied extensively in the context of antibody-drug conjugates (ADCs), few studies have examined the impact of homogenous labe...
Promiscuous Pseudomonas: Uptake of Non-Endogenous Ligands for Iron Acquisition [0.03%]
放纵的假单胞菌：非内源配体的摄取以获得铁元素
Anna R Kaplan,William M Wuest
Anna R Kaplan
Iron is an essential nutrient to nearly all living beings. However, its acquisition poses a significant challenge to many organisms, including most bacteria. One of the main iron uptake strategies employed by bacteria is the uptake of sider...