Hao Chen,Sohjeong Kim,Chi P Ting
Hao Chen
The total synthesis of (±)-3-thiaglutamate is reported. Central to our strategy is an thiol addition to an imine to form the thioaminal of the natural product. The resulting thioaminal product is then subjected to triflic acid global depro...
Synthesis of 3,3-Disubstituted Allyl Isoindolinones via Pd-Catalyzed Decarboxylative Allylic Alkylation [0.03%]
钯催化脱羧烯丙基烷基化合成3,3-双取代异吲哚啉-1-酮类化合物
Mario Alvarado,Marisa Loo,Hanna Adler et al.
Mario Alvarado et al.
Herein, we report a mild palladium-catalyzed decarboxylative allylic alkylation of allyl ester-substituted isoindolinone substrates to afford a variety of 3,3-disubstituted isoindolinone derivatives. The decarboxylative coupling reaction to...
Convenient Access to a Strained Bicyclic Enone: A Concise and Improved Formal Synthesis of Ineleganolide [0.03%]
简洁便利地构建双环内烯酮结构单位并完成甜菊烷型倍半萜 ineleganolide 的简便高效全合成及缩略合成研究
Benjamin M Gross,Brian M Stoltz
Benjamin M Gross
The norcembranoid and cembranoid diterpenoids represent an intriguing class of natural products isolated from marine sources. Their chemical synthesis has been a challenging and exciting field of research over the past two decades, owing la...
Three-component reductive alkylation of 2-hydroxy-1, 4-naphthoquinones with lactols [0.03%]
2-羟基-1,4-萘醌与 lactol 叠氮化合物的三组分还原烷基化反应
Eliana E Kim,Evans O Onyango,Jennifer R Pace et al.
Eliana E Kim et al.
Lactols II, obtained by DIBAL reduction of their corresponding lactones I, in equilibrium with their hydroxyaldehyde tautomers III were used in a three-component reductive alkylation with 2-hydroxy-1,4-naphthoquinone to give a series of 3-a...
Asymmetric Synthesis of an Atropisomeric β-Carboline via Regioselective Intermolecular Rh(I)-Catalyzed [2 + 2 + 2] Cyclotrimerization [0.03%]
铑催化区域选择性分子间[2+2+2]环三聚化合成对映异构联苯四氢β-咔啉化合物
Riley R Hughes,Lorenzo D Battistoni,Matthew J Ciesla et al.
Riley R Hughes et al.
The rational design of atropisomeric small molecules is becoming increasingly common in chemical synthesis as a result of the unique advantages this property provides in drug discovery, asymmetric catalysis, and chiroptical activity. In thi...
Homogeneous Organic Reductant Based on 4,4'-tBu2-2,2'-Bipyridine for Cross-Electrophile Coupling [0.03%]
基于4,4'-二叔丁基-2,2'-联吡啶的均相有机还原剂在交叉偶联反应中的应用
David J Charboneau,Haotian Huang,Emily L Barth et al.
David J Charboneau et al.
The synthesis of a new homogeneous reductant based on 4,4'-tBu2-2,2'-bipyridine, tBu-OED4, is reported. tBu-OED4 was prepared on a multigram scale in two steps from inexpensive and commercially available starting materials, with no chromato...
Jamie L Breunig,You-Chen Lin,Joshua G Pierce
Jamie L Breunig
Thienamycin is a carbapenem antibiotic with potent activity against gram-negative and gram-positive bacteria. Due to its promising activity but lack of chemical stability, thienamycin serves as inspiration for new synthetic antibiotic scaff...
Adam X Wayment,Nye C Johnson,Mariur Rodriguez Moreno et al.
Adam X Wayment et al.
We report that squaric esters can serve as bifunctional reagents for selective peptide stapling reactions. Formation of the squaric amide staple occurs under mild conditions with amine-containing side chains. We show that short resin-bound ...
Liesa Röder,Sofia Torres Venegas,Klaus Wurst et al.
Liesa Röder et al.
A 9-step synthetic route to a protected form of the C3-epimer of virenose from D-fucose is described. C3-epi-virenose is the carbohydrate unit of the bioactive polyketide elsamicin B and part of the carbohydrate unit of elsamicin A. The dev...
An Enzymatic Route to the Synthesis of Tricyclic Fused Hexahydrofuranofuran P2-Ligand for a Series of Highly Potent HIV-1 Protease Inhibitors [0.03%]
一种用于合成一系列高效抗HIV蛋白酶抑制剂的三环并合己氢呋喃菲P2配体的酶促途径
Arun K Ghosh,Ashish Sharma,Somayeh Ghazi
Arun K Ghosh
We describe a stereoselective synthesis of an optically active (1R, 3aS, 5R, 6S, 7aR)-octahydro-1,6-epoxy-isobenzo-furan-5-ol derivative. This stereochemically defined heterocycle serves as a high-affinity ligand for a variety of HIV-1 prot...